Department of Hepatology Gastroenterology and Infectious Diseases, Benha University, Faculty of Medicine, Banha, Egypt.
WHO Consultant, Research Coordinator at ERC-RCOG, Giza, Egypt.
J Environ Public Health. 2021 Jun 17;2021:6662476. doi: 10.1155/2021/6662476. eCollection 2021.
This study evaluated the clinical manifestation of COVID-19 and adverse outcomes in patients with comorbidities (outcome: death).
A comparative follow-up investigation involving 148 confirmed cases of COVID-19 was performed for a month (between April and May 2020) at Qaha Hospital to describe the clinical characteristics and outcomes resulting from comorbidities. Participants were divided into two clusters based on the presence of comorbidities. Group I comprised cases with comorbidities, and Group II included subjects without comorbidity. Survival distributions were outlined for the group with comorbidities after the follow-up period.
Fever (74.3%), headache (78.4%), cough (78.4%), sore throat (78.4%), fatigue (78.4%), and shortness of breath (86.5%) were the most prevalent symptoms observed in COVID-19 patients with comorbidities. Such patients also suffered from acute respiratory distress syndrome (37.8%) and pneumonia three times more than patients without comorbidities. The survival distributions were statistically significant (chi-square = 26.06, ≤ 0.001).
Multiple comorbidities in COVID-19 patients are linked to severe clinical symptoms, disease complications, and critical disease progression. The presence of one or more comorbidities worsened the survival rate of patients.
本研究评估了合并症患者（结局：死亡）COVID-19 的临床表现和不良结局。
在 2020 年 4 月至 5 月期间，在 Qaha 医院对 148 例 COVID-19 确诊病例进行了为期一个月的对比随访调查，以描述合并症引起的临床特征和结局。参与者根据合并症的存在分为两组。第 I 组包括有合并症的病例，第 II 组包括无合并症的受试者。对随访期后有合并症的组进行生存分布描述。
COVID-19 合并症患者最常见的症状为发热（74.3%）、头痛（78.4%）、咳嗽（78.4%）、咽痛（78.4%）、乏力（78.4%）和呼吸急促（86.5%）。这些患者还患有急性呼吸窘迫综合征（37.8%）和肺炎，其发生率是无合并症患者的三倍。生存分布具有统计学意义（卡方=26.06，p≤0.001）。
COVID-19 患者合并多种疾病与严重的临床症状、疾病并发症和疾病进展有关。存在一种或多种合并症会降低患者的生存率。
