伊朗北部巴博勒人群中新冠病毒的一年患病率及其循环阈值、合并症与结局之间的关联（2020 - 2021年）
One-year prevalence and the association between SARS-CoV-2 cycle threshold, comorbidity and outcomes in population of Babol, North of Iran (2020-2021).
作者信息
Halaji Mehrdad, Pournajaf Abazar, Sadeghi Farzin, Hasanzadeh Ali, Chehrazi Mohammad, Gholinia Hemmat, Hejazi Amiri Fatemeh, Saber Amoli Saghar, Javanian Mostafa, Bayani Masoumeh, Sadeghi Haddad Zavareh Mahmoud, Shokri Mehran, Babazadeh Arefeh, Bazi Broun Mana, Mohammadi Mohsen, Mehdinezhad Hamed, Monadi Mahmoud, Amri Maleh Parviz, Nouri Hamid Reza, Daraei Abdolreza, Yousefnia Pasha Mahdie, Tourani Mehdi, Ahmadian Seyed Raheleh, Esmailzadeh Nadia, Mirtabar Seyyedeh Maedeh, Asadi Shakiba, Yousefghahary Behnaz, Babaei Mansour, Nabipour Majid, Vakili Sadeghi Mohsen, Pourkia Roghayeh, Jafarypour Iraj, Zieaie Amiri Naghmeh, Akbary Roghayeh, Asgharpour Masoumeh, Oliaei Farshid, Zahedpasha Yadollah, Mahmoodi Hasan, Akbarian Rad Zahra, Haghshenas Mojaveri Mohsen, Seyfi Shahram, Shokri Shirvani Javad, Alhooee Saman, Abedi Hasan, Behzad Katrin, Bayani Mohammad Ali, Kheirkhah Farzan, Saadat Payam, Nasiraie Ebrahim, Ezami Nafiseh, Gorjinejad Shahrbano, Fallhpour Kobra, Fakhraie Fatemeh, Beheshti Yousef, Baghershiroodi Mahnaz, Rasti Faeze, Salehi Maryam, Aleahmad Atiyeh, Nasrollahian Sina, Babapour Rahman, Malekzadeh Rahim, Habibzadeh Kashi Rahmat, Shams Esmaili Mohammad Ali, Javadian Kotnaei Maryam, Ghanbarpour Azita, Yahyapour Yousef
机构信息
Infectious Diseases and Tropical Medicine Research Center, Health Research Institute, Babol University of Medical Sciences, Babol, Iran.
Department of Medical Microbiology, Faculty of Medicine, Babol University of Medical Sciences, Babol, Iran.
出版信息
Caspian J Intern Med. 2022;13(Suppl 3):244-253. doi: 10.22088/cjim.13.0.244.
BACKGROUND
The present study aimed to investigate the one-year prevalence of SARS-CoV-2, common comorbidities and demographic information among negative- and positive rRT-PCR in health care workers (HCW), hospitalized and outpatients. Also, the association between SARS-CoV-2 cycle threshold (Ct) and the outcomes of patients were analyzed in Babol, northern Iran.
METHODS
This large retrospective cross-sectional study was performed between March 2020 and March 2021. The records of 19232 hospitalized, outpatients and HCW suspected to COVID-19 were collected from teaching hospitals in the North of Iran.
RESULTS
Out of the 19232 suspected to COVID-19 patients, 7251 (37.7%) had a positive rRT-PCR result; 652 (9%), 4599 (63.4%) and 2000 (27.6%) of those were categorized as HCW, hospitalized and outpatients, respectively. Moreover, between the hospitalized and the outpatient group, 10.2 and 0.8% cases died, whereas no death cases were reported in the HCW. Furthermore, it seems that death rate was significantly different between the three groups of Ct value, the highest mortality in those with Ct between 21 and 30 (group B=7.6%) and the lowest in the group with the highest Ct (between 31 and 40 = 5.5%) (<0.001).
CONCLUSION
In summary, 37.7% of cases were positive for SARS-CoV-2; of which, 63.4, 27.6 and 9% were hospitalized, outpatients and HCW, respectively. With regard to the mortality rate in hospitalized patients and the significant association with Ct under 20 and 30, it seems that the early detection and the initial quantification of SARS-CoV-2 in the first week of the conflict and therapeutic considerations to reduce the relative load can reduce the mortality rate.
背景
本研究旨在调查伊朗北部巴博勒地区医护人员、住院患者和门诊患者中新冠病毒2型（SARS-CoV-2）的一年患病率、常见合并症及人口统计学信息。此外，还分析了SARS-CoV-2循环阈值（Ct）与患者预后之间的关联。
方法
这项大型回顾性横断面研究于2020年3月至2021年3月进行。从伊朗北部的教学医院收集了19232名疑似感染新冠病毒的住院患者、门诊患者和医护人员的记录。
结果
在19232名疑似新冠病毒感染患者中，7251例（37.7%）逆转录聚合酶链反应（rRT-PCR）结果呈阳性；其中652例（9%）为医护人员，4599例（63.4%）为住院患者，2000例（27.6%）为门诊患者。此外，住院组和门诊组的死亡率分别为10.2%和0.8%，而医护人员中未报告死亡病例。此外，Ct值的三组之间死亡率似乎有显著差异，Ct值在21至30之间的患者死亡率最高（B组=7.6%），Ct值最高的组（31至40之间=5.5%）死亡率最低（<0.001）。
结论
总之，37.7%的病例SARS-CoV-2检测呈阳性；其中，住院患者、门诊患者和医护人员分别占63.4%、27.6%和9%。鉴于住院患者的死亡率以及与Ct值低于20和30的显著关联，似乎在感染第一周对SARS-CoV-2进行早期检测和初始定量，并采取治疗措施以降低病毒相对载量，可降低死亡率。
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