Department of Social and Preventive Medicine, School of Public Health, University of Montreal, Montreal, Quebec, Canada
Centre for Public Health Research, University of Montreal, Montreal, Quebec, Canada.
BMJ Open. 2021 Jul 8;11(7):e053245. doi: 10.1136/bmjopen-2021-053245.
Further evidence is needed to understand the contribution of schools and daycares for the spread of COVID-19 in the context of diverse transmission dynamics and continually evolving public health interventions. The Enfants et COVID-19: Étude de séroprévalence (EnCORE) study will estimate the seroprevalence and seroconversion of SARS-CoV-2 among school and daycare children and personnel. In addition, the study will examine associations between seroprevalence and sociodemographic characteristics and reported COVID-19 symptoms and tests, and investigates changes in health, lifestyle and well-being outcomes.
This study includes children and personnel from 62 schools and daycares in four neighbourhoods in Montreal, Canada. All children aged 2-17 years attending one of the participating schools or daycares and their parents are invited to participate, as well as a sample of personnel members. Participants respond to brief questionnaires and provide blood samples, collected via dried blood spot, at baseline (October 2020-March 2021) and follow-up (May-June 2021). Questionnaires include sociodemographic and household characteristics, reported COVID-19 symptoms and tests, potential COVID-19 risk factors and prevention efforts and health and lifestyle information. Logistic regression using generalised estimating equations will be used to estimate seroprevalence and seroconversion, accounting for school-level clustering.
This study was approved by the research ethics boards of the Université de Montréal (CERSES) and the Centre Hospitalier Universitaire Sainte-Justine. Results will contribute to our knowledge about SARS-CoV-2 transmission in schools and daycares and will be made available to study participants and their families, school and public health decision-makers and the research community.
在不同的传播动态和不断变化的公共卫生干预措施的背景下，需要进一步的证据来了解学校和日托所在 COVID-19 传播中的作用。Enfants et COVID-19: Étude de séroprévalence (EnCORE) 研究将估计学校和日托儿童和工作人员中 SARS-CoV-2 的血清流行率和血清转化率。此外，该研究还将研究血清流行率与社会人口特征以及报告的 COVID-19 症状和检测之间的关联，并调查健康、生活方式和幸福感的变化。
本研究包括来自加拿大蒙特利尔四个社区的 62 所学校和日托所的儿童和工作人员。所有 2-17 岁的儿童，只要他们在参加的学校或日托所之一就读，他们的父母都会被邀请参加，以及工作人员的样本。参与者会回答简短的问卷并提供血液样本，通过干血斑收集，在基线（2020 年 10 月至 2021 年 3 月）和随访（2021 年 5 月至 6 月）时进行。问卷包括社会人口学和家庭特征、报告的 COVID-19 症状和检测、潜在的 COVID-19 风险因素和预防措施以及健康和生活方式信息。使用广义估计方程的逻辑回归将用于估计血清流行率和血清转化率，同时考虑到学校层面的聚类。
这项研究得到了蒙特利尔大学 (CERSES) 和圣贾斯汀大学中心医院的研究伦理委员会的批准。研究结果将有助于我们了解学校和日托所中 SARS-CoV-2 的传播情况，并将提供给研究参与者及其家属、学校和公共卫生决策者以及研究社区。
