Department of Parasitology, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran.
Social Determinants of Health Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Microb Pathog. 2021 Oct;159:105083. doi: 10.1016/j.micpath.2021.105083. Epub 2021 Jul 8.
Toxoplasma gondii and Mycobacterium tuberculosis are intracellular pathogens, both infecting a substantial proportion of human population. We conducted a systematic review and meta-analysis to estimate the pooled T. gondii seroprevalence in tuberculosis patients. Three international databases were systematically searched for literature on prevalence of T. gondii in tuberculosis patients. A total of 1389 documents were identified, and eight papers were eligible to be included in the systematic review and meta-analysis. Geographical data gaps were evident, as no studies were identified from many countries where both infections are important. The pooled seroprevalence of IgG, IgM, and both IgG and IgM antibodies against T. gondii in tuberculosis patients were estimated to be 35.9% (95% confidence interval [CI], 19.3-56.7%), 35.0% (95% CI, 3.0-90.3%), and 13.4% (95% CI, 2.4-49.0%), respectively. In the included case-control studies, the pooled T. gondii seroprevalence (proportion anti- T. gondii IgG antibody positive) was higher in tuberculosis patients than in their controls, with an odds ratio by random effects model of 1.63 (95% CI, 1.28-2.08). The results of our work suggest an association between T. gondii seropositivity and being a tuberculosis patient, which should however be interpreted with caution because the timeline of the infections and the disease process are not accounted for. Our work showed that T. gondii seropositivity, indicating chronic infection with the zoonotic parasite, was relatively common among tuberculosis patients.
刚地弓形虫和结核分枝杆菌都是细胞内病原体，都感染了相当一部分人类。我们进行了一项系统评价和荟萃分析，以估计结核病患者中弓形虫的总血清流行率。系统地检索了三个国际数据库，以查找关于结核病患者中弓形虫流行率的文献。共确定了 1389 份文件，其中 8 份符合纳入系统评价和荟萃分析的标准。明显存在地理数据差距，因为在许多同时存在这两种感染的重要国家，没有发现研究。结核病患者 IgG、IgM 和 IgG 和 IgM 抗体对弓形虫的总血清流行率估计分别为 35.9%（95%置信区间 [CI]，19.3-56.7%）、35.0%（95% CI，3.0-90.3%）和 13.4%（95% CI，2.4-49.0%）。在纳入的病例对照研究中，结核病患者的弓形虫血清流行率（抗弓形虫 IgG 抗体阳性比例）高于对照组，随机效应模型的汇总比值比为 1.63（95% CI，1.28-2.08）。我们的工作结果表明，弓形虫血清阳性与结核病患者之间存在关联，但应谨慎解释，因为感染和疾病过程的时间线未被考虑在内。我们的工作表明，刚地弓形虫血清阳性，表明与这种动物源性寄生虫的慢性感染，在结核病患者中较为常见。
