Jafari-Shakib Reza, Sadeghi Abbas, Majidi-Shad Bijan, Atrkar-Roshan Zahra, Sharifdini Meysam
Department of Immunology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
Department of Medical Parasitology, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
J Parasit Dis. 2024 Jun;48(2):247-252. doi: 10.1007/s12639-024-01657-3. Epub 2024 Mar 7.
Coinfection of tuberculosis (TB) and human parasitic infections is common in developing countries. There is little information about the prevalence of ( infection among TB patients in Iran. In this case-control study, anti-toxoplasma antibodies were measured by ELISA method in 100 patients with active tuberculosis and 100 healthy individuals who were matched in terms of sex, age, and place of residence. Anti- IgG antibodies were diagnosed in 62% of TB patients (95% CI 53-71%) and 70% of control subjects (95% CI 62-78%). Anti- IgM antibodies were found in 1% of both TB patients and control group. The seroprevalence of infection was not significantly different between TB patients and healthy individuals ( > 0.05). None of the assessed sociodemographic and behavioral factors was recognized as a risk factor for toxoplasmosis in TB infected patients. Moreover, the level of anti- IgG antibodies concentration in TB patients was significantly higher than in control subjects and revealed skewness towards humoral immune response in TB patients. Coinfection of toxoplasmosis and tuberculosis was prevalent but infection was independent of active TB in this co-endemic area.
结核病（TB）与人体寄生虫感染的合并感染在发展中国家很常见。关于伊朗结核病患者中弓形虫感染率的信息很少。在这项病例对照研究中，采用酶联免疫吸附测定（ELISA）法检测了100例活动性结核病患者和100名在性别、年龄和居住地点相匹配的健康个体的抗弓形虫抗体。62%的结核病患者（95%可信区间53 - 71%）和70%的对照者（95%可信区间62 - 78%）检测出抗IgG抗体。结核病患者和对照组中均有1%的人检测出抗IgM抗体。结核病患者和健康个体之间弓形虫感染的血清流行率无显著差异（P>0.05）。在评估的社会人口统计学和行为因素中，没有一个被认为是结核病感染患者弓形虫病的危险因素。此外，结核病患者中抗IgG抗体浓度水平显著高于对照者，表明结核病患者的体液免疫反应存在偏态。弓形虫病与结核病的合并感染很普遍，但在这个共同流行地区，弓形虫感染与活动性结核病无关。
