Genomic Medicine Laboratory UILDM, IRCCS Santa Lucia Foundation, Rome, Italy.
Department of Biomedicine and Prevention, Tor Vergata University, Rome, Italy.
Front Immunol. 2021 Jun 23;12:708820. doi: 10.3389/fimmu.2021.708820. eCollection 2021.
During the COVID19 pandemic, a range of vaccines displayed high efficacy in preventing disease, severe outcomes of infection, and mortality. However, the immunological correlates of protection, the duration of immune response, the transmission risk over time from vaccinated individuals are currently under active investigation. In this brief report, we describe the case of a vaccinated Healthcare Professional infected with a variant of Sars-CoV-2, who has been extensively investigated in order to draw a complete trajectory of infection. The patient has been monitored for the whole length of infection, assessing the temporal viral load decay, the quantification of viral RNA and subgenomic mRNA, antibodies (anti Sars-CoV-2, IgA, IgG, IgM) and cell-mediated (cytokine, B- and T-cell profiles) responses. Overall, this brief report highlights the efficacy of vaccine in preventing COVID19 disease, accelerating the recovery from infection, reducing the transmission risk, although the use of precautionary measures against Sars-CoV-2 spreading still remain critical.
在 COVID19 大流行期间，一系列疫苗在预防疾病、感染的严重后果和死亡率方面显示出了很高的疗效。然而，目前正在积极研究保护的免疫相关性、免疫反应的持续时间、接种个体随时间传播的风险。在本简要报告中，我们描述了一例接种疫苗的医疗保健专业人员感染 SARS-CoV-2 变异株的病例，为了描绘感染的完整轨迹，对该病例进行了广泛的调查。对该患者进行了全程感染监测，评估了病毒载量的时间衰减、病毒 RNA 和亚基因组 mRNA、抗体（抗 SARS-CoV-2、IgA、IgG、IgM）和细胞介导（细胞因子、B 和 T 细胞谱）反应。总体而言，本简要报告强调了疫苗在预防 COVID19 疾病、加速感染恢复、降低传播风险方面的功效，尽管仍需要采取预防措施来防止 SARS-CoV-2 的传播。
