Department of Nursing, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
Department of Psychiatry, Faculty of Medicine, Mbarara University of Science and Technology, Mbarara, Uganda.
BMC Psychiatry. 2021 Jul 12;21(1):350. doi: 10.1186/s12888-021-03316-w.
HIV-Associated Neurocognitive Disorder (HAND remains a pronounced consequence of HIV/AIDS despite improved life expectancies. This is often associated with several dysfunctions such as decrease of attention, mood alterations and psychomotor disturbances. Many factors, including age, gender, employment status, and psychiatric disorders, have been associated with HAND. Among the associated psychiatric disorders, depression is often more prevalent. It can influence not only quality of life, relationships and employment but also adherence to medical care. We assessed the prevalence of depression and its association with HAND among people living with HIV in rural Southwestern Uganda.
This was a cross-sectional study that used Beck Depression Inventory-1 and International HIV Dementia Scale to assess depression and HAND respectively. We defined depression with a score of > 10 and HAND with a cutoff score of ≤10. We conducted data analysis using STATA version 12, and Pearson Chi-square test and logistic regression to determine associations between depression and HAND. The level of statistical significance was set at p ≤ 0.05. Ethical approval and administrative clearance were obtained from relevant bodies.
Of the 393 participants assessed for depression and HAND, 27% had depression and 58.3% screened positive for HAND. All levels of depression were more prevalent among female participants. We found a significant association between depression and HIV associated neurocognitive disorders (χ2 (3) = 9.0538 p = 0.029).
Our findings confirmed a high prevalence of depression in individuals with HAND which is a major component of the disease burden.
尽管艾滋病毒/艾滋病患者的预期寿命有所延长，但与艾滋病毒相关的认知障碍（HAND）仍然是一种明显的后果。这通常与注意力下降、情绪改变和精神运动障碍等多种功能障碍有关。许多因素，包括年龄、性别、就业状况和精神障碍，与 HAND 有关。在相关的精神障碍中，抑郁症更为常见。它不仅会影响生活质量、人际关系和就业，还会影响对医疗的依从性。我们评估了在乌干达西南部农村地区生活的艾滋病毒感染者中HAND 患者的抑郁症患病率及其与 HAND 的相关性。
这是一项横断面研究，使用贝克抑郁量表-1 和国际艾滋病毒痴呆量表分别评估抑郁和 HAND。我们将评分>10 分定义为抑郁，评分≤10 分定义为 HAND。我们使用 STATA 版本 12 进行数据分析，采用 Pearson 卡方检验和逻辑回归来确定抑郁与 HAND 之间的关联。统计学显著性水平设定为 p≤0.05。已从相关机构获得伦理批准和行政许可。
在 393 名接受抑郁和 HAND 评估的参与者中，27%患有抑郁，58.3%HAND 筛查阳性。所有程度的抑郁在女性参与者中更为常见。我们发现抑郁与 HIV 相关的认知障碍之间存在显著关联（χ2（3）=9.0538，p=0.029）。
我们的研究结果证实了 HAND 患者中抑郁症的高患病率，这是疾病负担的一个主要组成部分。
