Department of Nutrition, School of Public Health, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Nutrition and Food Security Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran.
Phytother Res. 2021 Sep;35(9):5259-5268. doi: 10.1002/ptr.7199. Epub 2021 Jul 13.
This double-blind randomized clinical trial aimed to investigate impact of Cornus mas L. fruit extract (CMFE) on liver function in nonalcoholic fatty liver disease (NAFLD). Fifty patients were randomly assigned into the CMFE and placebo groups to receive 20 ml of the extract or placebo for 12 weeks, respectively. Serum alanine aminotransferase, aspartate aminotransferase, cytokeratin 18 (CK-18) levels, and steatosis and fibrosis scores were examined before and after the intervention. Although, a significant decrease was observed in CK-18 levels among the CMFE group (288.80 ± 85.40 vs. 235.66 ± 60.38; p = .001) after 12 weeks, no significant difference was found between the two groups. Moreover, a significant increase in fibrosis score in the placebo group (8.20 (6.35-9.40) vs. 8.40 (7.70-13.00); p = .03) as well as a significant difference in this marker (CMEF: 7.64 (6.30-8.25); placebo: 8.40 (7.70-13.00); p = .02) and its changes (CMEF: 0.60 (-1.00-1.07); placebo: 0.80 (-0.25-3.95); p = .02) were found between the groups after 12 weeks. No significant effect was noted on other variables. Therefore, consuming CMFE might have some beneficial effects on liver function markers in NAFLD. However, more studies are required in this area.
这项双盲随机临床试验旨在研究山茱萸果提取物（CMFE）对非酒精性脂肪性肝病（NAFLD）患者肝功能的影响。将 50 名患者随机分为 CMFE 组和安慰剂组，分别接受 20ml 提取物或安慰剂，干预 12 周。干预前后检测血清丙氨酸氨基转移酶、天冬氨酸氨基转移酶、细胞角蛋白 18（CK-18）水平及脂肪变性和纤维化评分。虽然 12 周后 CMFE 组 CK-18 水平显著下降（288.80±85.40 比 235.66±60.38；p=0.001），但两组间无显著差异。此外，安慰剂组纤维化评分显著升高（8.20（6.35-9.40）比 8.40（7.70-13.00）；p=0.03），且该标志物及其变化（CMFE：7.64（6.30-8.25）；安慰剂：8.40（7.70-13.00）；p=0.02）在两组间存在显著差异。其他变量无显著影响。因此，食用 CMFE 可能对 NAFLD 患者的肝功能标志物有一定的有益影响。但该领域还需要更多的研究。
