Department of Pharmaceutical Botany, Faculty of Pharmacy, "Iuliu Hațieganu" University of Medicine and Pharmacy, 23 Gheorghe Marinescu Street, 400337 Cluj-Napoca, Romania.
Department of Food Chemistry and Analysis, Institute of Food Technology and Food Chemistry, Technische Universität Berlin, Gustav-Meyer-Allee 25, 13355 Berlin, Germany.
Nutrients. 2024 Jul 8;16(13):2173. doi: 10.3390/nu16132173.
This meta-analysis aimed to summarise clinical evidence regarding the effect of supplementation with cornelian cherry ( L.) on different cardiometabolic outcomes. An extensive literature survey was carried out until 10 April 2024. A total of 415 participants from six eligible studies were included. The overall results from the random-effects model indicated that cornelian cherry supplementation significantly reduced body weight (standardised mean difference [SMD] = -0.27, confidence interval [CI]: -0.52, -0.02, = 0.03), body mass index (SMD = -0.42, CI: -0.73, -0.12, = 0.007), fasting blood glucose (SMD = -0.46, CI: -0.74, -0.18, = 0.001), glycated haemoglobin (SMD = -0.70, CI: -1.19, -0.22, = 0.005), and HOMA-IR (SMD = -0.89, CI: -1.62, -0.16, = 0.02), while high-density lipoprotein cholesterol significantly increased (SMD = 0.38, CI: 0.10, 0.65, = 0.007). A sensitivity analysis showed that cornelian cherry supplementation significantly reduced total plasma triglycerides, total cholesterol, low-density lipoprotein cholesterol, and insulin levels. Cornelian cherry supplementation did not significantly affect waist circumference and liver parameters among the participants. Considering these findings, this meta-analysis indicates that supplementation with cornelian cherry may impact diverse cardiometabolic risk factors among individuals considered to be at a high risk.
这项荟萃分析旨在总结关于补充山茱萸（L.）对不同心血管代谢结局影响的临床证据。进行了广泛的文献调查，直到 2024 年 4 月 10 日。共有来自六项合格研究的 415 名参与者被纳入。随机效应模型的总体结果表明，山茱萸补充剂显著降低体重（标准化均数差[SMD]=-0.27，置信区间[CI]：-0.52，-0.02， = 0.03）、体重指数（SMD=-0.42，CI：-0.73，-0.12， = 0.007）、空腹血糖（SMD=-0.46，CI：-0.74，-0.18， = 0.001）、糖化血红蛋白（SMD=-0.70，CI：-1.19，-0.22， = 0.005）和 HOMA-IR（SMD=-0.89，CI：-1.62，-0.16， = 0.02），而高密度脂蛋白胆固醇显著增加（SMD=0.38，CI：0.10，0.65， = 0.007）。敏感性分析表明，山茱萸补充剂显著降低总血浆甘油三酯、总胆固醇、低密度脂蛋白胆固醇和胰岛素水平。山茱萸补充剂对参与者的腰围和肝脏参数没有显著影响。考虑到这些发现，这项荟萃分析表明，补充山茱萸可能会影响被认为处于高风险的个体的多种心血管代谢风险因素。
