Omrani Morteza, Norouzzadeh Mostafa, Ahmadirad Hamid, Abbasi Mehrnaz, Jahromi Mitra Kazemi, Teymoori Farshad, Rashedi Minoo Hasan, Rahideh Seyedeh Tayebeh, Farhadnejad Hossein, Mirmiran Parvin, Khaleghian Mohsen
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran.
Nutrition and Endocrine Research Center, Research Institute for Endocrine Disorders, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Nutr Metab (Lond). 2025 Aug 6;22(1):92. doi: 10.1186/s12986-025-00991-4.
Given the essential role of cardiometabolic risk factors in the global burden of chronic diseases, this study aimed to assess the potential of cornelian cherry(.) in improving anthropometric parameters, lipid profile, glycemic indices, liver enzyme levels, and dietary intake of energy and macronutrients.
We conducted a systematic search of PubMed, Scopus, Web of Science, and the Cochrane Library for eligible randomized controlled trials(RCTs) published up to May 2025, with no restrictions on language or publication date. The weighted mean difference(WMD) and 95% confidence interval(95%CI) for each outcome were determined using a random-effects model. The certainty of the assessments was further examined using the GRADE assessment.
Seven RCTs were included in the final analysis. Pooled effect size showed that Cornus mas L(CM) intake significantly reduced body weight (MD:-0.57 Kg,95%CI:-1.03,-0.12; = 0.013), body mass index(MD:-0.38 kg/m,95%CI:-0.52,-0.23; = 0.001), fat mass (MD:-0.97%,95%CI:-1.53,-0.41; = 0.001), waist circumference (MD:-1.36 cm,95%CI:-1.80,-0.92; = 0.001), and hip circumference(MD:-0.95 cm,95%CI:-1.55,-0.36; = 0.002), triglycerides(MD:-30.6 mg/dl,95%CI:-61.0,-0.14; = 0.049), fasting blood sugar (FBS) (MD:-5.72 mg/dl,95%CI:-11.25,-0.20; = 0.042), and hemoglobin A1c(HbA1c)(MD:-0.28,95%CI:-0.35,-0.20; = 0.001). Additionally, CM increased high-density lipoprotein-cholesterol levels(MD:2.03 mg/dl,95%CI:0.82,3.25; = 0.001). However, we observed no significant effects of CM intake on total cholesterol levels, low-density lipoprotein-cholesterol, insulin, aspartate aminotransferase, and alanine aminotransferase.
The findings of our meta-analysis indicate that consuming CM can positively affect CMR factors. These benefits include improved anthropometric parameters, including body weight, body mass index, fat mass, waist circumference, and hip circumference, a reduction in glycemic parameters such as FBS and HbA1c, and an improvement in lipid profile. However, the study did not reveal any significant impact of CM consumption on insulin, total cholesterol, and liver enzyme levels.
The online version contains supplementary material available at 10.1186/s12986-025-00991-4.
鉴于心脏代谢危险因素在全球慢性病负担中的重要作用，本研究旨在评估山茱萸在改善人体测量参数、血脂谱、血糖指数、肝酶水平以及能量和宏量营养素饮食摄入方面的潜力。
我们对PubMed、Scopus、Web of Science和Cochrane图书馆进行了系统检索，以查找截至2025年5月发表的符合条件的随机对照试验（RCT），对语言和出版日期无限制。使用随机效应模型确定每个结局的加权平均差（WMD）和95%置信区间（95%CI）。使用GRADE评估进一步检查评估的确定性。
最终分析纳入了7项RCT。汇总效应大小显示，摄入山茱萸（CM）可显著降低体重（MD：-0.57千克，95%CI：-1.03，-0.12；P = 0.013）、体重指数（MD：-0.38千克/米²，95%CI：-0.52，-0.23；P = 0.001）、脂肪量（MD：-0.97%，95%CI：-1.53，-0.41；P = 0.001）、腰围（MD：-1.36厘米，95%CI：-1.80，-0.92；P = 0.001）和臀围（MD：-0.95厘米，95%CI：-1.55，-0.36；P = 0.002），甘油三酯（MD：-30.6毫克/分升，95%CI：-61.0，-0.14；P = 0.049）、空腹血糖（FBS）（MD：-5.72毫克/分升，95%CI：-11.25，-0.20；P = 0.042）和糖化血红蛋白（HbA1c）（MD：-0.28，95%CI：-0.35，-0.20；P = 0.001）。此外，CM可提高高密度脂蛋白胆固醇水平（MD：2.03毫克/分升，95%CI：0.82，3.25；P = 0.001）。然而，我们观察到摄入CM对总胆固醇水平、低密度脂蛋白胆固醇、胰岛素、天冬氨酸转氨酶和丙氨酸转氨酶无显著影响。
我们的荟萃分析结果表明，食用CM可对心脏代谢危险因素产生积极影响。这些益处包括改善人体测量参数，如体重、体重指数、脂肪量、腰围和臀围，降低血糖参数如FBS和HbA1c，以及改善血脂谱。然而，该研究未发现食用CM对胰岛素、总胆固醇和肝酶水平有任何显著影响。
在线版本包含可在10.1186/s12986-025-00991-4获取的补充材料。
