Department of Ophthalmology, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, China.
Department of Ophthalmology, The First Affiliated Hospital of Jiangxi Medical College, Shangrao, Jiangxi 330000, China.
Biomed Res Int. 2020 Dec 2;2020:7526185. doi: 10.1155/2020/7526185. eCollection 2020.
To measure the macular retinal vessel density (VD) and peripapillary retinal nerve fiber layer (RNFL) in primary angle-closure suspects (PACS) by Angio-OCT to be compared with normal subjects.
Primary angle-closure suspect patients and normal subjects were enrolled in this study. The demographic and clinical characteristics of all subjects, such as RNFL thickness, retinal vessel density, and ocular perfusion pressure, were compared.
No significant difference was found in both groups on age, sex distribution, intraocular pressure (IOP), and retinal vessel density. The PACS group exhibited significantly thicker RNFL thickness compared with the control group. The deep vessel density was negatively associated with age ( = -0.034), while IOP had negative association with ACD ( = -0.019). OPP was independently associated with RNFL ( = 0.334, = 0.038) in the PACS group.
OCTA showed significant thicker change on RNFL in the PACS group. Only OPP was independently associated with RNFL in the PACS group.
通过 Angio-OCT 测量原发性闭角型青光眼疑似患者的黄斑视网膜血管密度（VD）和视盘周围视网膜神经纤维层（RNFL），并与正常受试者进行比较。
本研究纳入了原发性闭角型青光眼疑似患者和正常受试者。比较了所有受试者的人口统计学和临床特征，如 RNFL 厚度、视网膜血管密度和眼灌注压。
两组在年龄、性别分布、眼压（IOP）和视网膜血管密度方面均无显著差异。与对照组相比，PACS 组的 RNFL 厚度明显较厚。深层血管密度与年龄呈负相关（r=-0.034），而 IOP 与 ACD 呈负相关（r=-0.019）。在 PACS 组中，OPP 与 RNFL 独立相关（r=0.334，p=0.038）。
OCTA 显示 PACS 组的 RNFL 有明显的增厚变化。只有 OPP 在 PACS 组中与 RNFL 独立相关。
