Sultzer B M
J Immunol. 1978 Jan;120(1):254-61.
Thymus-independent (B) lymphocytes from BCG-infected mice respond with enhanced or depressed levels of proliferation relative to the nonspecific levels of stimulation induced by tuberculin. The type of response obtained depends on how BCG was administered and the source of the lymphocytes. The proliferation of splenic B lymphocytes was depressed when BCG was given i.v. and unchanged when BCG was given subcutaneously, whereas the lymph node B cell response was enhanced regardless of the route of injecting BCG. BCG was found also to be a mitogen for normal B cells in vitro and to stimulate polyclonal activation of B cells in vivo. Finally, evidence is presented which indicates that the depressed splenic B cell response to tuberculin may be due to the activation of suppressor T cells.
与结核菌素诱导的非特异性刺激水平相比，来自卡介苗感染小鼠的非胸腺依赖性（B）淋巴细胞的增殖水平会增强或降低。所获得的反应类型取决于卡介苗的给药方式和淋巴细胞的来源。静脉注射卡介苗时，脾脏B淋巴细胞的增殖受到抑制，而皮下注射卡介苗时则无变化，而无论卡介苗的注射途径如何，淋巴结B细胞反应都会增强。还发现卡介苗在体外是正常B细胞的促有丝分裂原，并能在体内刺激B细胞的多克隆激活。最后，有证据表明脾脏B细胞对结核菌素反应的抑制可能是由于抑制性T细胞的激活。
