Zatz M M
J Immunol. 1976 Jun;116(6):1587-91.
The effects of Bacillus-Calmette Guerin (BCG) administration upon lymphocyte traffic was studied in BALB/cJ mice. Intravenous or subcutaneous injection of BCG resulted in increased localization (trapping) of 51Cr-labeled syngeneic lymphocytes in the spleen or draining nodes. BCG-induced splenic trapping was biphasic, occurring 1 to 2 days after BCG injection, and reappearing 3 weeks later. Trapping in draining lymph nodes persisted and increased during the 24 days of study. These results are in contrast to those obtained with SRBC, where trapping was evident only within the first few days of antigen injection. Additional studies revealed that prior injection of BCG influencdd the ensuing magnitude of SRBC-induced trapping. Intravenous administration of BCG suppressed SRBC-induced splenic trapping; both intravenous and subcutaneous injection of BCG enhanced trapping to SRBC in the draining lymph nodes. These studies suggest that one mechanism for potentiation of immune responses by BCG may operate via BCG's effects upon regulation of lymphocyte traffic to the lymphoid tissues.
在BALB/cJ小鼠中研究了卡介苗（BCG）接种对淋巴细胞迁移的影响。静脉注射或皮下注射卡介苗会导致51Cr标记的同基因淋巴细胞在脾脏或引流淋巴结中的定位（滞留）增加。卡介苗诱导的脾脏滞留是双相的，在卡介苗注射后1至2天出现，并在3周后再次出现。在研究的24天内，引流淋巴结中的滞留持续存在并增加。这些结果与用绵羊红细胞（SRBC）获得的结果形成对比，在SRBC实验中，滞留仅在抗原注射后的头几天明显。进一步的研究表明，预先注射卡介苗会影响随后SRBC诱导的滞留程度。静脉注射卡介苗会抑制SRBC诱导的脾脏滞留；静脉注射和皮下注射卡介苗都会增强引流淋巴结中对SRBC的滞留。这些研究表明，卡介苗增强免疫反应的一种机制可能是通过卡介苗对淋巴细胞向淋巴组织迁移的调节作用来实现的。
