Department of Obstetrics and Gynecology, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt.
Department of Clinical Pathology, Faculty of Medicine, Menoufia University, Shebin Elkom, Egypt.
Gynecol Obstet Invest. 2021;86(4):336-342. doi: 10.1159/000517117. Epub 2021 Jul 14.
The aim of the present study was to evaluate the effect of autologous platelet-rich plasma (PRP) on wound healing and pain perception after cesarean section in high-risk patients.
This was a prospective randomized controlled trial. Participants/Materials, Settings, and Methods: This was a randomized controlled trial of 200 patients who came to the outpatient clinic of Menoufia University Hospital for elective cesarean surgery. The women were randomly assigned to 2 equal groups. The intervention group received PRP subcutaneous injection in the wound after surgery; however, the control group received the usual care. Outcome variables included the redness, edema, ecchymosis, discharge, approximation (REEDA) scale, Vancouver scar scale (VSS), and in addition to the visual analog scale (VAS).
From April 2018 to July 2020, the PRP group showed a greater reduction in the REEDA score compared to the control group on day 1, day 7, and this was continued till 6 months (1.51 ± 0.90 vs. 2.49 ± 1.12, p < 0.001). Compared with the control group, the PRP group had a significantly greater reduction in the VSS and VAS scores beginning on the seventh day (3.71 ± 0.99 vs. 4.67 ± 1.25, p < 0.001) and (5.06 ± 1.10 vs. 6.02 ± 1.15, p < 0.001), respectively, and continued till 6 months.
Pain was not measured by the use of analgesics, and we did not investigate the effects of varying platelet concentrations, centrifuge duration, or speed.
PRP has positive effects on wound healing and pain reduction in high-risk patients undergoing cesarean section in low-resource settings.
本研究旨在评估富含血小板的血浆（PRP）对高危剖宫产患者术后伤口愈合和疼痛感知的影响。
这是一项前瞻性随机对照试验。
参与者/材料、设置和方法：这是一项随机对照试验，纳入了 200 名前来 Menoufia 大学医院门诊行择期剖宫产术的患者。这些女性被随机分配到两组。干预组在术后于伤口处接受 PRP 皮下注射；而对照组则接受常规护理。观察指标包括红肿、水肿、瘀斑、渗液、愈合（REEDA）评分、温哥华瘢痕评分（VSS）以及视觉模拟评分（VAS）。
自 2018 年 4 月至 2020 年 7 月，PRP 组在术后第 1、7 天和第 6 个月时的 REEDA 评分均明显低于对照组（1.51 ± 0.90 比 2.49 ± 1.12，p < 0.001）。与对照组相比，PRP 组在术后第 7 天开始 VSS 和 VAS 评分显著降低（3.71 ± 0.99 比 4.67 ± 1.25，p < 0.001）和（5.06 ± 1.10 比 6.02 ± 1.15，p < 0.001），并一直持续至第 6 个月。
疼痛未通过使用镇痛药进行测量，我们也未调查血小板浓度、离心时长和速度等因素的影响。
PRP 对资源匮乏环境下高危剖宫产患者的伤口愈合和疼痛减轻具有积极影响。
