CRISPR-Cas9基因编辑技术在癌症研究中的应用综述。
Review of applications of CRISPR-Cas9 gene-editing technology in cancer research.
作者信息
Zhao Ziyi, Li Chenxi, Tong Fei, Deng Jingkuang, Huang Guofu, Sang Yi
机构信息
The Third Affiliated Hospital of Nanchang University, Nanchang, 330008, China.
Orthodontic Department of Affiliated Stomatological Hospital of Nanchang University, Nanchang, 330008, China.
出版信息
Biol Proced Online. 2021 Jul 15;23(1):14. doi: 10.1186/s12575-021-00151-x.
Characterized by multiple complex mutations, including activation by oncogenes and inhibition by tumor suppressors, cancer is one of the leading causes of death. Application of CRISPR-Cas9 gene-editing technology in cancer research has aroused great interest, promoting the exploration of the molecular mechanism of cancer progression and development of precise therapy. CRISPR-Cas9 gene-editing technology provides a solid basis for identifying driver and passenger mutations in cancer genomes, which is of great value in genetic screening and for developing cancer models and treatments. This article reviews the current applications of CRISPR-Cas9 gene-editing technology in various cancer studies, the challenges faced, and the existing solutions, highlighting the potential of this technology for cancer treatment.
癌症以多种复杂突变为特征，包括癌基因激活和肿瘤抑制基因抑制，是主要死因之一。CRISPR-Cas9基因编辑技术在癌症研究中的应用引起了极大兴趣，推动了对癌症进展分子机制的探索以及精准治疗的发展。CRISPR-Cas9基因编辑技术为识别癌症基因组中的驱动突变和乘客突变提供了坚实基础，这在基因筛查以及开发癌症模型和治疗方法方面具有重要价值。本文综述了CRISPR-Cas9基因编辑技术在各类癌症研究中的当前应用、面临的挑战以及现有的解决方案，突出了该技术在癌症治疗方面的潜力。
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