Department of Dermatology and Allergy, Herlev and Gentofte Hospital, University of Copenhagen, DK-2900 Hellerup, Denmark. E-mail:
Acta Derm Venereol. 2021 Jul 30;101(7):adv00512. doi: 10.2340/00015555-3882.
Advances in technology have led to an increased number of studies investigating the microbiome in patients with psoriasis. This systematic review examined data regarding the oral and gut microbiota in patients with psoriasis and/or psoriatic arthritis and the effect of probiotics on the microbiota and severity of psoriasis. Of 1,643 studies, 23 were included (22 observational, 1 interventional). Studies examined the microbiota using culture or 16S rRNA gene sequencing analysis. All culture-based studies identified an increased presence of oral Candida in patients with psoriasis, whereas small variations in the oral microbiota were found in a 16S rRNA gene-based study. All 16S rRNA gene sequencing based studies agreed that the gut microbiota of patients with psoriatic disease differed from that of healthy controls, but the results were heterogeneous. Probiotics were associated with a significant improvement in the severity of psoriasis, but did not change microbiota. Overall, studies lacked relevant inclusion criteria and baseline information. In conclusion, the role of the microbiota in patients with psoriasis requires further investigation using more robust methods.
技术的进步使得越来越多的研究关注银屑病患者的微生物组。本系统评价检查了银屑病和/或银屑病关节炎患者的口腔和肠道微生物组以及益生菌对微生物组和银屑病严重程度的影响的数据。在 1643 项研究中，纳入了 23 项研究（22 项观察性研究，1 项干预性研究）。研究使用培养或 16S rRNA 基因测序分析来检查微生物组。所有基于培养的研究都发现银屑病患者口腔中念珠菌的存在增加，而基于 16S rRNA 基因的研究则发现口腔微生物组存在微小变化。所有基于 16S rRNA 基因测序的研究都认为银屑病患者的肠道微生物组与健康对照组不同，但结果存在异质性。益生菌与银屑病严重程度的显著改善相关，但不会改变微生物组。总体而言，这些研究缺乏相关的纳入标准和基线信息。总之，需要使用更强大的方法进一步研究微生物组在银屑病患者中的作用。
