定制铅屏蔽和过滤器的开发，用于伽马细胞室中的小鼠靶向辐照。

Faculty of Medicine, Universiti Teknologi MARA, 47200, Sungai Buloh, Selangor, Malaysia.

Faculty of Dentistry, Universiti Teknologi MARA, 47200, Sungai Buloh, Selangor, Malaysia.

Sci Rep. 2021 Jul 15;11(1):14559. doi: 10.1038/s41598-021-93964-5.

We presented a development of a custom lead shield and mouse strainer for targeted irradiation from the gamma-cell chamber. This study was divided into two parts i.e., to (i) fabricate the shield and strainer from a lead (Pb) and (ii) optimize the irradiation to the mice-bearing tumour model with 2 and 8 Gy absorbed doses. The lead shielding was fabricated into a cuboid shape with a canal on the top and a hole on the vertical side for the beam path. Respective deliveries doses of 28 and 75 Gy from gamma-cell were used to achieve 2 and 8 Gy absorbed doses at the tumour sites.

我们提出了一种从伽马室进行靶向照射的定制铅屏蔽和鼠标滤网的开发。这项研究分为两部分，即(i)用铅（Pb）制造屏蔽和滤网，以及(ii)用 2 和 8 Gy 吸收剂量优化对携带肿瘤模型的小鼠的照射。铅屏蔽被制成一个长方体形状，顶部有一个通道，垂直侧面有一个孔用于光束路径。使用伽马室的各自 28 和 75 Gy 的剂量输送，以在肿瘤部位实现 2 和 8 Gy 的吸收剂量。