Department of Medicine, King Fahad Military Medical Complex, Dhahran, Saudi Arabia.
Infectious Disease Unit, King Fahad Military Medical Complex, Dhahran, Saudi Arabia.
J Epidemiol Glob Health. 2021 Sep;11(3):316-319. doi: 10.2991/jegh.k.210521.001. Epub 2021 Jun 2.
There is no specific anti-viral therapies for 2019 Coronavirus Diseases (COVID-19) infection. Here, we compared patients receiving steroids at different dosages versus no steroids in severe and critical COVID-19 patients.
We retrospectively studied COVID-19 patients who received low-dose or high-dose corticosteroid therapy compared to no steroid.
The study period, June-August 2020, included 169 patients with COVID-19 were included and there were 39.1% female and 60.9% male with an average age of 53.1 years. The distribution of cases was as follows: high-dose 39 (23.1%), low-dose 54 (32.0%), and no steroid 76 (45.5%). Of all the patients, Intensive Care Unit (ICU) admission was for 31 (18.3%), nine (5.3%) required intubation, and 52 (30.8%) had no comorbidities. There is no difference in the mean age between the different groups. However, those being treated with steroid were more likely to have a high sequential organ failure assessment (SOFA) score (0.37 ± 0.68, 0.36 ± 0.67 and 0.04 ± 0.34, for low-dose, high-dose steroid and no steroid groups, respectively ( = 0.001). Cox regression was not possible as the mortality rate was very low (3/169; 1.78%) and none of the multivariate methods would be possible. However, there was a significant difference in the hospital Length of stay (LOS) and the ICU LOS.
Cox regression was not possible as the mortality rate was very low (1.78%) and none of the multivariate methods would be possible as the model will not converge. However, in -test only, intubation was associated risk of mortality.
目前针对 2019 年冠状病毒病（COVID-19）感染还没有特定的抗病毒疗法。在这里，我们比较了重症和危重症 COVID-19 患者中接受不同剂量类固醇治疗与未接受类固醇治疗的患者。
我们回顾性研究了接受低剂量或高剂量皮质类固醇治疗与未使用类固醇的 COVID-19 患者。
研究期间为 2020 年 6 月至 8 月，共纳入 169 例 COVID-19 患者，其中女性占 39.1%，男性占 60.9%，平均年龄为 53.1 岁。病例分布如下：高剂量组 39 例（23.1%），低剂量组 54 例（32.0%），无激素组 76 例（45.5%）。所有患者中，有 31 例（18.3%）收入重症监护病房（ICU），9 例（5.3%）需要插管，52 例（30.8%）无合并症。不同组间的平均年龄无差异。然而，接受激素治疗的患者序贯器官衰竭评估（SOFA）评分更高（低剂量、高剂量激素和无激素组分别为 0.37±0.68、0.36±0.67 和 0.04±0.34， = 0.001）。由于死亡率非常低（169 例中 3 例；1.78%），无法进行 Cox 回归，也无法使用任何多变量方法。然而，住院时间（LOS）和 ICU LOS 有显著差异。
由于死亡率非常低（1.78%），无法进行 Cox 回归，也无法使用任何多变量方法，因为模型无法收敛。然而，仅通过 t 检验，插管是死亡的危险因素。
