King Fahad Military Medical Complex, Dhahran, Saudi Arabia.
Infectious Disease Unit, Specialty Internal Medicine, Dhahran, Saudi Arabia.
Eur J Med Res. 2022 Jun 28;27(1):101. doi: 10.1186/s40001-022-00729-5.
The connection between initial viral cycle threshold (Ct) values of the SARS-CoV-2 with symptoms and hospital course is not clearly studied.
This is a retrospective study of hospitalized COVID-19 patients from Jun 1st 2020 to March 30th, 2021 examining the relationship between initial viral cycle threshold (Ct) values of SARS-CoV-2 as obtained from nasopharyngeal samples. The clinical presentations and outcomes were analyzed in relation to the initial Ct values.
The study included 202 hospitalized COVID-19 patients with a mean age (± SD) of 54.75 (± 15.93) and 123 (60.9%) males and 79 (39.1%) females. Of all the patients, the most frequent comorbidity was diabetes mellitus (95; 47%) and the most frequent symptoms were fever (148; 73.3%) and cough (141; 69.8%). There was no significant difference in relation to underlying conditions, clinical presentation, radiographic and laboratory data among those with low, medium and high Ct values. The mean Ct values showed no statistical change over the 10-month study period.
Initial SARS-CoV-2 Ct values did not show any association with clinical symptoms and did not predict the need for mechanical intubation or death.
SARS-CoV-2 初始病毒循环阈值（Ct）值与症状和住院病程之间的关系尚未得到明确研究。
这是一项回顾性研究，纳入了 2020 年 6 月 1 日至 2021 年 3 月 30 日期间住院的 COVID-19 患者，研究了鼻咽样本中 SARS-CoV-2 初始病毒循环阈值（Ct）值与临床症状和结局的关系。
该研究纳入了 202 例住院 COVID-19 患者，平均年龄（±标准差）为 54.75（±15.93）岁，男性 123 例（60.9%），女性 79 例（39.1%）。所有患者中最常见的合并症是糖尿病（95 例，47%），最常见的症状是发热（148 例，73.3%）和咳嗽（141 例，69.8%）。低、中、高 Ct 值患者的基础疾病、临床症状、影像学和实验室数据无显著差异。Ct 值均值在 10 个月的研究期间无统计学变化。
SARS-CoV-2 初始 Ct 值与临床症状无明显关联，也不能预测是否需要机械通气或死亡。
