Graduate School of Life and Environmental Sciences, University of Tsukuba, Tsukuba, Ibaraki, Japan.
Biosci Biotechnol Biochem. 2021 Sep 22;85(10):2169-2176. doi: 10.1093/bbb/zbab132.
Kaempferol (KPF) is a dietary polyphenol reported to have various beneficial effects on human health. However, its molecular mechanisms in regulating lipid and glucose metabolism are not fully understood. This study examined the effects of KPF on obesity, dyslipidemia, and diabetes in Tsumura, Suzuki, Obese Diabetes mice. The 6-week administration of KPF decreased fat weight, serum total cholesterol, and low-density lipoproteins (LDLs); increased high-density lipoproteins (HDLs); and improved glucose tolerance. Additionally, KPF increased LDL receptor (LDLR) and apolipoprotein A1 (ApoA1) gene expression and decreased serum resistin levels. These findings suggest that the decrease in LDL and the increase in HDL caused by KPF may be due to increases in hepatic LDLR and ApoA1 expression, respectively. Furthermore, it is possible that the improvement in glucose tolerance by KPF may occur via resistin reduction. These mechanisms may be parts of complex mechanism by which KPF improves metabolic syndrome.
山奈酚（KPF）是一种饮食多酚，据报道对人类健康有多种有益作用。然而，其调节脂质和葡萄糖代谢的分子机制尚不完全清楚。本研究探讨了 KPF 对 Tsumura、Suzuki、肥胖型糖尿病小鼠肥胖、血脂异常和糖尿病的影响。KPF 的 6 周给药可降低脂肪重量、血清总胆固醇和低密度脂蛋白（LDL）；增加高密度脂蛋白（HDL）；并改善葡萄糖耐量。此外，KPF 增加了 LDL 受体（LDLR）和载脂蛋白 A1（ApoA1）基因的表达，并降低了血清抵抗素水平。这些发现表明，KPF 引起的 LDL 降低和 HDL 升高可能分别归因于肝 LDLR 和 ApoA1 表达的增加。此外，KPF 改善葡萄糖耐量可能是通过降低抵抗素来实现的。这些机制可能是 KPF 改善代谢综合征的复杂机制的一部分。
