增强子在三维基因组中导航，以指导细胞命运决定。

Enhancers navigate the three-dimensional genome to direct cell fate decisions.

机构信息

Laboratory of Cellular and Developmental Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

出版信息

Curr Opin Struct Biol. 2021 Dec;71:101-109. doi: 10.1016/j.sbi.2021.06.005. Epub 2021 Jul 16.

DOI:10.1016/j.sbi.2021.06.005

PMID:34280668

Abstract

The activity and selectivity of transcriptional enhancers determine gene expression patterns that enable a zygote to become a complex organism. How enhancers convey regulatory information is a central conundrum in biology. Here, we discuss recent progress provided by rapidly evolving technologies in understanding enhancer-promoter interactions in the context of overall nuclear genome organization.

摘要

转录增强子的活性和选择性决定了基因表达模式，使受精卵能够发育成复杂的生物体。增强子如何传递调控信息是生物学中的一个核心难题。在这里，我们讨论了在整体核基因组组织背景下，通过快速发展的技术在理解增强子-启动子相互作用方面取得的最新进展。