Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan.
Department of Urology, Nagasaki University Graduate School of Biomedical Sciences, Nagasaki, Japan
Anticancer Res. 2021 Aug;41(8):3815-3823. doi: 10.21873/anticanres.15174.
BACKGROUND/AIM: A previous report showed that immune complex-ceruloplasmin (CP) in urine is associated with carcinogenesis and malignant behavior in bladder cancer (BC). We investigated the pathological significance and prognostic roles of urine and tissue levels of CP protein in BC patients.
Urine CP levels were measured using an enzyme-linked immunosorbent assay in 97 patients. CP expression in BC tissues was evaluated by immunohistochemical analysis in 176 patient samples.
Urine CP levels were positively associated with tumor grade and pT stage in non-muscle invasive BC (NMIBC). CP expression in BC tissues was positively associated with tumor growth and progression. Multivariate analysis demonstrated that high urine CP levels was an independent predictor of recurrence in the urinary tract in NMIBC (hazard ratio=2.87, p=0.016).
CP-related markers, especially urine CP levels, are useful biomarkers of malignant potential and prognosis in NMIBC.
背景/目的：先前的报告表明，尿液中的免疫复合物-铜蓝蛋白（CP）与膀胱癌（BC）的发生和恶性行为有关。我们研究了 CP 蛋白在 BC 患者尿液和组织中的水平的病理意义和预后作用。
在 97 例患者中使用酶联免疫吸附试验测量尿液 CP 水平。通过免疫组织化学分析评估 176 例患者样本中 BC 组织中的 CP 表达。
尿液 CP 水平与非肌肉浸润性膀胱癌（NMIBC）的肿瘤分级和 pT 分期呈正相关。BC 组织中的 CP 表达与肿瘤生长和进展呈正相关。多变量分析表明，高尿液 CP 水平是 NMIBC 尿路上皮复发的独立预测因子（危险比=2.87，p=0.016）。
CP 相关标志物，尤其是尿液 CP 水平，是 NMIBC 恶性潜能和预后的有用生物标志物。
