Department of Respiratory and Critical Care Medicine, West China Hospital of Sichuan University, Chengdu, China.
Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, China.
Ann Med. 2021 Dec;53(1):1198-1206. doi: 10.1080/07853890.2021.1949486.
This study aimed to validate the chronic obstructive pulmonary disease (COPD) Population Screener (COPD-PS) questionnaire as a screening tool in a cohort of Chinese subjects who underwent a health examination, and to summarise its overall performance through a meta-analysis. We enrolled 997 subjects aged ≥40 years who underwent a health examination, both lung function and COPD-PS data were collected. The screening performance of COPD-PS was evaluated with a receiver operating characteristic (ROC) curve analysis, using the area under the curve (AUC) to assess the screening accuracy. A standard diagnostic meta-analysis was used to summarise the screening performance of COPD-PS for COPD. Of the 997 subjects, 157 were identified as having COPD. The COPD-PS score was significantly higher in COPD patients than controls (5.03 ± 5.11 vs. 2.72 ± 1.80, < .001). At a cut-off of 4, the sensitivity and specificity of COPD-PS for identifying COPD were 74.52 and 70.24%, respectively, with an AUC of 0.79. Eight studies (including this study) were included in this meta-analysis. The pooled estimates for COPD-PS were as follows: sensitivity of 0.66 (95% CI: 0.47-0.63), specificity of 0.86 (95% CI: 0.84-0.89), positive likelihood ratio of 3.00 (95% CI: 1.65-5.47), negative likelihood ratio of 0.43 (95% CI: 0.35-0.52) and diagnostic odds ratio of 7.24 (95% CI: 3.91-13.40). The AUC of the summary ROC curve was 0.78. COPD-PS appears to be a useful tool for screening individuals with a high risk of COPD and guiding the selection of individuals for subsequent spirometry examination.KEY MESSAGESCOPD-PS is a simple and useful method to screen COPD.The combination of COPD-PS with other tools may improve the screen performance.
这项研究旨在验证慢性阻塞性肺疾病（COPD）人群筛查问卷（COPD-PS）作为一种筛查工具，用于接受健康检查的中国人群，并通过荟萃分析总结其整体性能。我们招募了 997 名年龄≥40 岁的受试者，这些受试者接受了健康检查，同时收集了肺功能和 COPD-PS 数据。使用受试者工作特征（ROC）曲线分析评估 COPD-PS 的筛查性能，使用曲线下面积（AUC）评估筛查准确性。使用标准诊断荟萃分析总结 COPD-PS 对 COPD 的筛查性能。在 997 名受试者中，有 157 名被诊断为 COPD。COPD 患者的 COPD-PS 评分明显高于对照组（5.03±5.11 与 2.72±1.80，<0.001）。在截值为 4 时，COPD-PS 识别 COPD 的灵敏度和特异性分别为 74.52%和 70.24%，AUC 为 0.79。这项研究共纳入了 8 项研究。这项荟萃分析的汇总估计值如下：COPD-PS 的灵敏度为 0.66（95%CI：0.47-0.63），特异性为 0.86（95%CI：0.84-0.89），阳性似然比为 3.00（95%CI：1.65-5.47），阴性似然比为 0.43（95%CI：0.35-0.52），诊断比值比为 7.24（95%CI：3.91-13.40）。汇总 ROC 曲线的 AUC 为 0.78。COPD-PS 似乎是一种有用的工具，可以筛查 COPD 高危人群，并指导选择后续进行肺功能检查的人群。关键信息COPD-PS 是一种简单且有用的 COPD 筛查方法。COPD-PS 与其他工具结合使用可能会提高筛查性能。
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