Diabetes Research Program, New York University Grossman Medical Center, New York, NY.
J Exp Med. 2021 Sep 6;218(9). doi: 10.1084/jem.20211098. Epub 2021 Jul 20.
In obesity complicated by hypertension, multicellular processes integrate to orchestrate cardiac fibrosis; the underlying mechanisms, however, remain elusive. In this issue of JEM, Cheng et al. (2021. J. Exp. Med. https://doi.org/10.1084/jem.20210252) describe adipocyte-macrophage collaboration to foster cardiac fibrosis through the actions of angiotensin II in obesity.
在肥胖合并高血压的情况下，多种细胞过程整合起来协调心脏纤维化；然而，潜在的机制仍难以捉摸。在本期的《实验医学杂志》中，程等人（2021. J. Exp. Med. https://doi.org/10.1084/jem.20210252）描述了脂肪细胞-巨噬细胞通过肥胖中的血管紧张素 II 的作用协同促进心脏纤维化。
