Department of Cardiology, Radboud University Medical Center, Geert Grooteplein Zuid 10, 6525 GA, Nijmegen, The Netherlands.
Department of Physiology, Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, The Netherlands.
Int J Cardiovasc Imaging. 2021 Dec;37(12):3459-3467. doi: 10.1007/s10554-021-02346-5. Epub 2021 Jul 20.
In patients hospitalized for corona virus infectious disease 19 (COVID-19) it is currently unknown whether myocardial function changes after recovery and whether this is related to elevated cardiac biomarkers. In this single center, prospective cohort study we consecutively enrolled hospitalized COVID-19 patients between 1 April and 12 May 2020. All patients underwent transthoracic echocardiography (TTE) evaluation during hospitalization and at a median of 131 days (IQR; 116-136) follow-up. Of the 51 patients included at baseline, 40 (age: 62 years (IQR; 54-68), 78% male) were available for follow-up TTE. At baseline, 68% of the patients had a normal TTE, regarding left ventricular (LV) and right ventricular (RV) volumes and function, compared to 83% at follow-up (p = 0.07). Median LV ejection fraction (60% vs. 58%, p = 0.54) and tricuspid annular plane systolic excursion (23 vs 22 mm, p = 0.18) were comparable between hospitalization and follow-up, but a significantly lower RV diameter (39 vs. 34 mm, p = 0.002) and trend towards better global longitudinal strain (GLS) (- 18.5% vs - 19.1%, p = 0.07) was found at follow-up. Subgroup analysis showed no relation between patients with and without elevated TroponinT and/or NT-proBNP during hospitalization and myocardial function at follow-up. Although there were no significant differences in individual myocardial function parameters at 4 months follow-up compared to hospitalisation for COVID-19, there was an overall trend towards normalization in myocardial function, predominantly due to a higher rate of normal GLS at follow-up.
在因冠状病毒病 19（COVID-19）住院的患者中，目前尚不清楚恢复期心肌功能是否会发生变化，以及这种变化是否与升高的心脏生物标志物有关。在这项单中心前瞻性队列研究中，我们连续纳入了 2020 年 4 月 1 日至 5 月 12 日期间住院的 COVID-19 患者。所有患者在住院期间和中位随访 131 天（IQR；116-136）时均接受了经胸超声心动图（TTE）评估。在基线时，51 名患者中有 40 名（年龄：62 岁（IQR；54-68），78%为男性）可进行随访 TTE。在基线时，与随访时（68%对 83%，p=0.07）相比，68%的患者 TTE 左心室（LV）和右心室（RV）容积和功能正常。LV 射血分数（60%对 58%，p=0.54）和三尖瓣环平面收缩期位移（23 对 22mm，p=0.18）在住院期间和随访期间相似，但 RV 直径（39 对 34mm，p=0.002）明显较低，并且 GLS（-18.5%对-19.1%，p=0.07）呈改善趋势。亚组分析显示，住院期间升高的肌钙蛋白 T 和/或 NT-proBNP 与随访时的心肌功能之间无相关性。尽管与 COVID-19 住院期间相比，在 4 个月随访时，个体心肌功能参数无明显差异，但心肌功能总体呈正常化趋势，主要是由于随访时正常 GLS 比例较高。
