Shirai Ai, Ogura Ichiro
Quantitative Diagnostic Imaging, Field of Oral and Maxillofacial Imaging and Histopathological Diagnostics, Course of Applied Science, The Nippon Dental University Graduate School of Life Dentistry at Niigata, 1-8 Hamaura-Cho, Chuo-Ku, Niigata, Niigata, 951-8580, Japan.
Department of Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata, 1-8 Hamaura-Cho, Chuo-Ku, Niigata, Niigata, 951-8580, Japan.
Odontology. 2025 Apr;113(2):857-863. doi: 10.1007/s10266-024-01014-z. Epub 2024 Oct 4.
Recently, SPECT/CT plays an important role in assessing patients with head and neck lesions. The aim of this study was performed to investigate the maximum standardized uptake value (SUV) for parotid and submandibular glands in patients with Sjögren's syndrome and submandibular sialolithiasis using salivary gland SPECT/CT. A prospective study was performed in 45 patients with 32 Sjögren's syndrome and 13 submandibular sialolithiasis who underwent salivary gland SPECT/CT. The SUV of parotid and submandibular glands was obtained using a workstation and software. The salivary secretion function of parotid and submandibular glands was defined as ratio of pre- to post-stimulation on SUV. A p value lower than 0.05 was considered as statistically significant. The SUV for parotid glands in patients with Sjögren's syndrome at pre-stimulation (18.0 ± 14.3), post-stimulation (12.0 ± 9.4), and ratio of pre- to post-stimulation (1.46 ± 0.52) were significantly lower than those of submandibular sialolithiasis (44.9 ± 8.4 (p < 0.001), 17.8 ± 6.5 (p < 0.001), and 2.75 ± 0.79 (p < 0.001), respectively). The SUV for submandibular glands in patients with Sjögren's syndrome at pre-stimulation (16.9 ± 18.7) were significantly lower than those with sialolithiasis (36.7 ± 27.8, p = 0.004) and without sialolithiasis (39.7 ± 16.0, p = 0.001) in patients with submandibular sialolithiasis. The salivary gland SPECT/CT SUV can be useful in clinical practice for the quantitative management of parotid and submandibular glands in patients with Sjögren's syndrome and submandibular sialolithiasis.
最近，SPECT/CT在评估头颈部病变患者中发挥着重要作用。本研究旨在利用唾液腺SPECT/CT研究干燥综合征和下颌下涎石病患者腮腺和下颌下腺的最大标准化摄取值（SUV）。对45例接受唾液腺SPECT/CT检查的患者进行了一项前瞻性研究，其中32例为干燥综合征患者，13例为下颌下涎石病患者。使用工作站和软件获取腮腺和下颌下腺的SUV。腮腺和下颌下腺的唾液分泌功能定义为刺激前后SUV的比值。p值低于0.05被认为具有统计学意义。干燥综合征患者腮腺在刺激前（18.0±14.3）、刺激后（12.0±9.4）以及刺激前后比值（1.46±0.52）的SUV均显著低于下颌下涎石病患者（分别为44.9±8.4（p<0.001）、17.8±6.5（p<0.001）和2.75±0.79（p<0.001））。干燥综合征患者下颌下腺在刺激前（16.9±18.7）的SUV显著低于下颌下涎石病患者（36.7±27.8，p=0.004）以及无涎石病的下颌下涎石病患者（39.7±16.0，p=0.001）。唾液腺SPECT/CT SUV在临床实践中可用于干燥综合征和下颌下涎石病患者腮腺和下颌下腺的定量管理。
