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Ethical Issues in Kidney Transplant and Donation During COVID-19 Pandemic.COVID-19 大流行期间肾移植和捐赠中的伦理问题。
Semin Nephrol. 2022 Jul;42(4):151272. doi: 10.1016/j.semnephrol.2022.07.006. Epub 2022 Jul 15.
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Issues regarding COVID-19 in kidney transplantation in the ERA of the Omicron variant: a commentary by the ERA Descartes Working Group.奥密克戎变异株时代肾移植中与 COVID-19 相关的问题:欧洲器官移植协会笛卡尔工作组的评论。
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Considering a COVID-19 vaccine mandate for pediatric kidney transplant candidates. 考虑对儿科肾移植候选人实施 COVID-19 疫苗强制接种。
Pediatr Nephrol. 2022 Nov;37(11):2559-2569. doi: 10.1007/s00467-022-05511-7. Epub 2022 Mar 25.
4
COVID-19 Vaccine Refusal and Organ Transplantation.新冠病毒疾病(COVID-19)疫苗接种拒绝与器官移植
Am J Kidney Dis. 2022 Jun;79(6):771-773. doi: 10.1053/j.ajkd.2022.02.009. Epub 2022 Mar 4.
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Transplantation programs facing lack of empirical evidence on SARS-CoV-2 vaccination: A society recommendation consensus update.移植项目面临缺乏 SARS-CoV-2 疫苗接种经验证据的问题:社会建议共识更新。
Transpl Infect Dis. 2021 Aug;23(4):e13696. doi: 10.1111/tid.13696. Epub 2021 Jul 28.

本文引用的文献

1
COVID-19-related mortality in kidney transplant and haemodialysis patients: a comparative, prospective registry-based study.COVID-19 相关死亡率在肾移植和血液透析患者中的比较:基于前瞻性登记的研究。
Nephrol Dial Transplant. 2021 Nov 9;36(11):2094-2105. doi: 10.1093/ndt/gfab200.
2
Kidney Transplant Recipient Attitudes Toward a SARS-CoV-2 Vaccine.肾移植受者对严重急性呼吸综合征冠状病毒2疫苗的态度
Transplant Direct. 2021 Jun 10;7(7):e713. doi: 10.1097/TXD.0000000000001171. eCollection 2021 Jul.
3
Impaired humoral immunity to SARS-CoV-2 BNT162b2 vaccine in kidney transplant recipients and dialysis patients.肾移植受者和透析患者对 SARS-CoV-2 BNT162b2 疫苗的体液免疫受损。
Sci Immunol. 2021 Jun 15;6(60). doi: 10.1126/sciimmunol.abj1031.
4
Antibody and T Cell Response to SARS-CoV-2 Messenger RNA BNT162b2 Vaccine in Kidney Transplant Recipients and Hemodialysis Patients.肾移植受者和血液透析患者对 SARS-CoV-2 信使 RNA BNT162b2 疫苗的抗体和 T 细胞反应。
J Am Soc Nephrol. 2021 Sep;32(9):2147-2152. doi: 10.1681/ASN.2021040480. Epub 2021 Jun 10.
5
Impaired humoral and cellular immunity after SARS-CoV-2 BNT162b2 (tozinameran) prime-boost vaccination in kidney transplant recipients.肾移植受者中 SARS-CoV-2 BNT162b2(tozinameran)疫苗加强接种后体液和细胞免疫受损。
J Clin Invest. 2021 Jul 15;131(14). doi: 10.1172/JCI150175.
6
High immunogenicity of a messenger RNA-based vaccine against SARS-CoV-2 in chronic dialysis patients.mRNA 疫苗对慢性透析患者 SARS-CoV-2 具有高免疫原性。
Nephrol Dial Transplant. 2021 Aug 27;36(9):1704-1709. doi: 10.1093/ndt/gfab193.
7
Antibody Response to 2-Dose SARS-CoV-2 mRNA Vaccine Series in Solid Organ Transplant Recipients.实体器官移植受者对两剂严重急性呼吸综合征冠状病毒2信使核糖核酸疫苗系列的抗体反应。
JAMA. 2021 Jun 1;325(21):2204-2206. doi: 10.1001/jama.2021.7489.
8
International estimates of intended uptake and refusal of COVID-19 vaccines: A rapid systematic review and meta-analysis of large nationally representative samples.国际上对 COVID-19 疫苗接种意愿和拒绝率的估计:基于大样本的全国代表性快速系统评价和荟萃分析。
Vaccine. 2021 Apr 8;39(15):2024-2034. doi: 10.1016/j.vaccine.2021.02.005. Epub 2021 Feb 6.
9
Predictors of COVID-19 vaccine hesitancy in the UK household longitudinal study.英国家庭纵向研究中 COVID-19 疫苗犹豫的预测因素。
Brain Behav Immun. 2021 May;94:41-50. doi: 10.1016/j.bbi.2021.03.008. Epub 2021 Mar 11.
10
COVID-19 Vaccination Hesitancy in the United States: A Rapid National Assessment.美国对 COVID-19 疫苗接种的犹豫:一项快速的全国评估。
J Community Health. 2021 Apr;46(2):270-277. doi: 10.1007/s10900-020-00958-x. Epub 2021 Jan 3.

肾移植与拒绝接种 SARS-CoV-2 疫苗的患者:伦理框架。

Kidney transplantation and patients who decline SARS-CoV-2 vaccination: an ethical framework.

机构信息

Guy's & St Thomas' NHS Foundation Trust, London, UK.

King's College London, London, UK.

出版信息

Transpl Int. 2021 Oct;34(10):1770-1775. doi: 10.1111/tri.13979. Epub 2021 Sep 19.

DOI:10.1111/tri.13979
PMID:34288160
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8420428/
Abstract

As SARS-CoV-2 vaccines have started to be rolled out, a key question facing transplant units has been whether listing for transplantation should be contingent on recipients having received a vaccine. We aimed to provide an ethical framework when considering potential transplant candidates who decline vaccination. We convened a working group comprising transplant professionals, lay members and patients and undertook a literature review and consensus process. This group's work was also informed by discussions in two hospital clinical ethics committees. We have reviewed arguments for and against mandating vaccination prior to listing for kidney transplantation and considered some practical difficulties which may be associated with a policy of mandated vaccination. Rather than requiring that all patients must receive the SARS-CoV-2 vaccine prior to transplant listing, we recommend considering vaccination status as one of a number of SARS-CoV-2-related risk factors in relation to transplant listing. Transplant units should engage in individualised risk-benefit discussions with patients, avoid the language of mandated treatments and strongly encourage uptake of the vaccine in all patient groups, using tailor-made educational initiatives.

摘要

随着 SARS-CoV-2 疫苗开始推出,移植单位面临的一个关键问题是,是否应将移植列入名单取决于接受者是否接种了疫苗。我们旨在为考虑拒绝接种疫苗的潜在移植候选人提供一个伦理框架。我们召集了一个由移植专业人员、非专业成员和患者组成的工作组,进行了文献回顾和共识过程。该工作组的工作还参考了两个医院临床伦理委员会的讨论。我们审查了在为肾移植进行名单登记之前接种疫苗的利弊,并考虑了与强制接种疫苗相关的一些实际困难。我们建议将疫苗接种状况作为与移植名单相关的 SARS-CoV-2 相关风险因素之一来考虑,而不是要求所有患者在移植前必须接种 SARS-CoV-2 疫苗。移植单位应与患者进行个体化的风险-效益讨论,避免使用强制治疗的语言,并通过量身定制的教育计划,在所有患者群体中大力鼓励接种疫苗。