State Key Laboratory of Rice Biology, China National Center for Rice Improvement, China National Rice Research Institute, Hangzhou 310006, China.
Maize Research Station, Ayub Agricultural Research Institute, Faisalabad 38000, Pakistan.
J Agric Food Chem. 2021 Aug 4;69(30):8307-8323. doi: 10.1021/acs.jafc.1c02653. Epub 2021 Jul 21.
Zero hunger is one of the sustainable development goals set by the United Nations in 2015 to achieve global food security by 2030. The current harvest of crops is insufficient; feeding the world's population and meeting the goal of zero hunger by 2030 will require larger and more consistent crop production. Clustered regularly interspaced short palindromic repeats-associated protein (CRISPR-Cas) technology is widely used for the plant genome editing. In this review, we consider this technology as a potential tool for achieving zero hunger. We provide a comprehensive overview of CRISPR-Cas technology and its most important applications for food crops' improvement. We also conferred current and potential technological breakthroughs that will help in breeding future crops to end global hunger. The regulatory aspects of deploying this technology in commercial sectors, bioethics, and the production of transgene-free plants are also discussed. We hope that the CRISPR-Cas system will accelerate the breeding of improved crop cultivars compared with conventional breeding and pave the way toward the zero hunger goal.
零饥饿是联合国在 2015 年设定的可持续发展目标之一，旨在到 2030 年实现全球粮食安全。目前的作物收成不足；要满足全球人口的需求，实现到 2030 年零饥饿的目标，就需要更大规模、更持续的作物生产。成簇规律间隔短回文重复相关蛋白（CRISPR-Cas）技术广泛用于植物基因组编辑。在这篇综述中，我们将这项技术视为实现零饥饿的潜在工具。我们全面概述了 CRISPR-Cas 技术及其在改良粮食作物方面的最重要应用。我们还讨论了当前和潜在的技术突破，这些突破将有助于培育未来的作物，以结束全球饥饿。我们还讨论了在商业领域、生物伦理和生产无转基因植物方面部署这项技术的监管方面。我们希望 CRISPR-Cas 系统能够比传统的育种方法更快地培育出改良的作物品种，为实现零饥饿目标铺平道路。
