脑类器官作为朊病毒疾病的新模型。 - Suppr

Cerebral organoids as a new model for prion disease.

作者信息

Groveman Bradley R, Smith Anna, Williams Katie, Haigh Cathryn L

机构信息

Prion Cell Biology Unit, Laboratory of Persistent Viral Diseases, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, Montana, United States of America.

出版信息

PLoS Pathog. 2021 Jul 21;17(7):e1009747. doi: 10.1371/journal.ppat.1009747. eCollection 2021 Jul.

DOI:10.1371/journal.ppat.1009747

PMID:34288977

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8294539/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7df/8294539/6c93ee1f1fdd/ppat.1009747.g001.jpg

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Cerebral organoids as a new model for prion disease.脑类器官作为朊病毒疾病的新模型。

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本文引用的文献

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Sci Rep. 2021 Mar 9;11(1):5165. doi: 10.1038/s41598-021-84689-6.

Human iPSC-Based Modeling of Central Nerve System Disorders for Drug Discovery.基于人诱导多能干细胞的中枢神经系统疾病模型用于药物发现。

Int J Mol Sci. 2021 Jan 26;22(3):1203. doi: 10.3390/ijms22031203.

Microglia in Prion Diseases: Angels or Demons?朊病毒病中的小胶质细胞：天使还是恶魔？

Int J Mol Sci. 2020 Oct 20;21(20):7765. doi: 10.3390/ijms21207765.

Electrophysiological Maturation of Cerebral Organoids Correlates with Dynamic Morphological and Cellular Development.类脑器官的电生理成熟与动态形态和细胞发育相关。

Stem Cell Reports. 2020 Oct 13;15(4):855-868. doi: 10.1016/j.stemcr.2020.08.017. Epub 2020 Sep 24.

Pathogens. 2020 Jun 18;9(6):482. doi: 10.3390/pathogens9060482.

Using our mini-brains: cerebral organoids as an improved cellular model for human prion disease.利用我们的“迷你大脑”：类脑器官作为人类朊病毒病的改良细胞模型

Neural Regen Res. 2020 Jun;15(6):1019-1020. doi: 10.4103/1673-5374.270300.

Neuronal maturation reduces the type I IFN response to orthobunyavirus infection and leads to increased apoptosis of human neurons.神经元成熟会降低对正粘病毒感染的 I 型干扰素反应，导致人神经元凋亡增加。

J Neuroinflammation. 2019 Nov 18;16(1):229. doi: 10.1186/s12974-019-1614-1.

Sporadic Creutzfeldt-Jakob disease prion infection of human cerebral organoids.散发性克雅氏病朊病毒感染的人类脑类器官。

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Neuroinflammation, Microglia, and Cell-Association during Prion Disease.朊病毒病期间的神经炎症、小胶质细胞和细胞关联。

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Cerebral organoids as a new model for prion disease.

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