Ng Yuen-Fann, Ng Ebonne, Lim Ee-Wei, Prakash Kumar M, Tan Louis C S, Tan Eng-King
Duke-NUS Medical School, 8 College Road, Singapore, 169857, Singapore.
Department of Neurology, National Neuroscience Institute, 11 Jalan Tan Tock Seng, Singapore, 308433, Singapore.
NPJ Parkinsons Dis. 2021 Jul 21;7(1):63. doi: 10.1038/s41531-021-00202-w.
We evaluate the association of hypertension with PD in an Asian population and performed a meta-analysis on similar studies to address the effect of hypertension on PD risk. A matched case-control study involving 1342 Chinese subjects (671 PD and 671 age and gender-matched controls (with a mean age of 63.9 ± 9.7 and 63.5 ± 9.8 years, and identical proportion of gender distribution) was conducted. Hypertension increases PD risk by 1.9 times [OR 1.86 (1.46-2.38)]. The literature search identified 618 studies initially; however, only three matched case-control studies (all in Caucasians) met the inclusion criteria for meta-analysis. Overall analysis showed that hypertension decreases PD risk by 0.2 times [OR 0.80 (0.66-0.96)]. Hypertension increases PD risk by 1.9 times in our Asian population. However, a meta-analysis comprising of Caucasian populations showed a protective effect of hypertension suggesting that ethnic differences or other genetic or environmental factors may contribute to the divergent observation. Early diagnosis and treatment of hypertension may potentially reduce the risk of PD, at least in our population.
我们评估了亚洲人群中高血压与帕金森病（PD）之间的关联，并对类似研究进行了荟萃分析，以探讨高血压对PD风险的影响。开展了一项匹配病例对照研究，涉及1342名中国受试者（671例PD患者和671名年龄及性别匹配的对照者，平均年龄分别为63.9±9.7岁和63.5±9.8岁，性别分布比例相同）。高血压使PD风险增加1.9倍[比值比（OR）为1.86（1.46 - 2.38）]。文献检索最初识别出618项研究；然而，只有三项匹配病例对照研究（均为白种人）符合荟萃分析的纳入标准。总体分析表明，高血压使PD风险降低0.2倍[OR为0.80（0.66 - 0.96）]。在我们的亚洲人群中，高血压使PD风险增加1.9倍。然而，对白种人群体进行的荟萃分析显示高血压具有保护作用，这表明种族差异或其他遗传或环境因素可能导致了这种不同的观察结果。至少在我们的人群中，高血压的早期诊断和治疗可能会潜在降低PD风险。
