Department of Surgery, College of Medicine, The Catholic University of Korea, 06591, Seoul, Republic of Korea.
Division of Endocrinology and Metabolism, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, 06591, Seoul, Republic of Korea.
Sci Rep. 2021 Jul 21;11(1):14908. doi: 10.1038/s41598-021-94461-5.
Male patients have a significantly higher prevalence of advanced-stage thyroid cancer. However, sex differences in the risk of differentiated thyroid carcinoma (DTC) recurrence have not been fully elucidated. Therefore, the present study aimed to investigate male sex as a prognostic factor for DTC. We assessed 5566 patients with DTC who underwent thyroid surgery between January 2009 and December 2015 at Seoul St. Mary's Hospital (Seoul, Korea). Clinicopathological characteristics and long-term oncologic outcomes between female and male patients with DTC were compared using propensity score matching to reduce selection bias. The mean follow-up duration was 99.9 ± 18.7 months. The recurrence rate was significantly higher in male patients than female patients before matching (3.3% vs. 2.2%, p = 0.030), and there was no significant difference in recurrence rates between the matched groups after matching (3.0% vs. 2.5%, p = 0.591). Based on Kaplan-Meier analysis, the two groups did not significantly differ in disease-free survival after matching. Multivariate analysis revealed that male sex was not an independent prognostic factor of DTC recurrence. Male sex did not have a significant effect on DTC recurrence. Further studies with larger cohorts are required to validate the findings of this study.
男性患者甲状腺癌晚期的患病率明显更高。然而，性别差异对分化型甲状腺癌（DTC）复发风险的影响尚未完全阐明。因此，本研究旨在探讨男性性别作为 DTC 的预后因素。我们评估了 2009 年 1 月至 2015 年 12 月期间在韩国首尔圣玛丽医院接受甲状腺手术的 5566 例 DTC 患者。使用倾向评分匹配来减少选择偏差，比较女性和男性 DTC 患者的临床病理特征和长期肿瘤学结果。平均随访时间为 99.9 ± 18.7 个月。在匹配前，男性患者的复发率明显高于女性患者（3.3%比 2.2%，p=0.030），匹配后两组的复发率无显著差异（3.0%比 2.5%，p=0.591）。基于 Kaplan-Meier 分析，匹配后两组的无病生存率无显著差异。多因素分析显示，男性性别不是 DTC 复发的独立预后因素。男性性别对 DTC 复发没有显著影响。需要更大队列的进一步研究来验证本研究的结果。
