Service de Neurologie, Centre Hospitalier Universitaire, Toulouse, France; France CHU de Toulouse, Université de Toulouse-Toulouse 3, INSERM, UMR1214 Toulouse NeuroImaging Centre "TONIC," Center of Excellence in Neurodegeneration (CoEN), NeuroToul, Centre Expert Parkinson de Toulouse, Centre d'Investigation Clinique CIC1436, NS-Park/FCRIN Network, Services de Neurologie et de Pharmacologie Clinique, UMR 1048 Institute for Cardiovascular Diseases, Toulouse, France.
Service de Neurologie, Centre Hospitalier Universitaire, Toulouse, France.
Parkinsonism Relat Disord. 2021 Aug;89:128-133. doi: 10.1016/j.parkreldis.2021.07.013. Epub 2021 Jul 13.
In 2020 the coronavirus disease 19 (COVID-19) pandemic imposed a total and sudden lockdown. We aimed to investigate the consequences of the first COVID-19 lockdown (mid-March - mid-April 2020) on motor and non-motor symptoms (NMS) in a cohort of French people with Parkinson's disease (PwP).
PwP were enrolled either by an on-line survey sent from the national France Parkinson association (FP) to reach the French community of PwP or as part of outpatients' telemedicine visits followed by an hospital-based Parkinson Expert Center (PEC). All patients were evaluated using the same standardized questionnaire assessing motor and NMS (including a list of most disabling, new or worsened symptoms and Patient's Global Impression-Improvement scales [PGI-I]) psycho-social queries and quality of life.
2653 PwP were included: 441 (16.6%) in the PEC group and 2122 (83.4%) in the community-based group. Physiotherapy was interrupted among 88.6% of the patients. 40.9% referred a clinical modification of their symptoms. Based on the questionnaire, pain (9.3%), rigidity (9.1%) and tremor (8.5%) were the three most frequently new or worsened reported symptoms. Based on the PGI-I, the motor symptoms were the most affected domain, followed by pain and psychic state. PwP in community-based group tended to have more frequent worsening for motor symptoms, motor complications, pain and confusion than those of the PEC group.
The first COVID-19 lockdown had a negative impact on motor and NMS of PwP. Efforts should be allocated to avoid interruption of care, including physiotherapy and physical activities and implement telemedicine. .
2020 年，新型冠状病毒病（COVID-19）大流行导致全面且突然的封锁。我们旨在调查 2020 年 3 月中旬至 4 月中旬的首次 COVID-19 封锁对法国帕金森病（PD）患者队列的运动和非运动症状（NMS）的影响。
通过向法国帕金森协会（FP）在线发送调查来招募 PD 患者，以覆盖法国 PD 患者群体，或通过远程医疗就诊纳入门诊患者，随后纳入医院帕金森专家中心（PEC）。所有患者均使用相同的标准化问卷评估运动和 NMS（包括最具致残性、新发或恶化的症状列表以及患者总体印象改善量表[PGI-I]）、心理社会问题和生活质量。
共纳入 2653 名 PD 患者：PEC 组 441 名（16.6%），社区组 2122 名（83.4%）。88.6%的患者中断了物理治疗。40.9%的患者报告其症状出现临床变化。根据问卷，疼痛（9.3%）、僵硬（9.1%）和震颤（8.5%）是报告的最常见的新发或恶化的症状。根据 PGI-I，运动症状是受影响最严重的领域，其次是疼痛和心理状态。社区组的 PD 患者在运动症状、运动并发症、疼痛和意识模糊方面更易恶化，而非 PEC 组。
首次 COVID-19 封锁对 PD 患者的运动和 NMS 产生了负面影响。应努力避免中断护理，包括物理治疗和体育活动，并实施远程医疗。
