Plant Ewan P, Ye Zhiping
Laboratory of Pediatric and Respiratory Viral Disease, Office of Vaccines Research and Review, CBER, FDA, Silver Spring, MD, United States.
Front Genet. 2021 Jul 6;12:699141. doi: 10.3389/fgene.2021.699141. eCollection 2021.
A new codon-pair bias present in the genomes of different types of influenza virus is described. Codons with fewer network interactions are more frequency paired together than other codon-pairs in influenza A, B, and C genomes. A shared feature among three different influenza types suggests an evolutionary bias. Codon-pair preference can affect both speed of protein translation and RNA structure. This newly identified bias may provide insight into drivers of virus evolution.
本文描述了不同类型流感病毒基因组中存在的一种新的密码子对偏好。在甲型、乙型和丙型流感病毒基因组中，网络相互作用较少的密码子比其他密码子对更频繁地配对在一起。三种不同流感类型之间的一个共同特征表明存在进化偏好。密码子对偏好既可以影响蛋白质翻译速度，也可以影响RNA结构。这种新发现的偏好可能有助于深入了解病毒进化的驱动因素。
