State Key Laboratory of Materials-Oriented Chemical Engineering, College of Food Science and Light Industry, Nanjing Tech University, Nanjing 211816, China.
School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China.
Int J Biol Macromol. 2021 Sep 30;187:91-104. doi: 10.1016/j.ijbiomac.2021.07.115. Epub 2021 Jul 20.
Developing a wound dressing for the treatment of large and irregular-shaped wounds remains a great challenge. Herein we developed novel printable bionic hydrogels with antibacterial and antioxidant properties which could effectively overcome the challenge by inhibiting inflammation and accelerating wound healing. The CMC/PL (CP) hydrogels were customized with glycidyl methacrylate (GMA) modified carboxymethyl cellulose (CMC) and ε-polylysine (ε-PL) via ultraviolet (UV) light polymerization using a 3D printer. Except for the high compression modulus (238 kPa), stable rheological properties, and effective degradability, these CP hydrogels also had an excellent inhibitory effect (95%) on both Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). Remarkably, CP hydrogels could remove the excessive reactive oxygen species (ROS) and protect the fibroblasts from damage. Compared with the commercial dressing (Tegaderm ™ film), CP hydrogels showed a better ability to increase the expression of VEGF and CD31, accelerate granulation tissue regeneration, and promote wound healing. This work provides a new strategy to fabricate on-demand multi-functional hydrogels in the field of skin tissue engineering.
开发用于治疗大尺寸和不规则形状伤口的创面敷料仍然是一个巨大的挑战。在此，我们开发了具有抗菌和抗氧化性能的新型可打印仿生水凝胶，通过抑制炎症和加速伤口愈合，有效地克服了这一挑战。通过 3D 打印机使用紫外 (UV) 光聚合，将甲基丙烯酰氧基丙基改性羧甲基纤维素 (CMC) 和 ε-聚赖氨酸 (ε-PL) 定制到 CMC/PL (CP) 水凝胶中。除了高压缩模量（238 kPa）、稳定的流变性能和有效降解性外，这些 CP 水凝胶对大肠杆菌 (E. coli) 和金黄色葡萄球菌 (S. aureus) 也具有出色的抑制作用（95%）。值得注意的是，CP 水凝胶可以去除过多的活性氧 (ROS)，并保护成纤维细胞免受损伤。与商业敷料 (Tegaderm ™ 膜) 相比，CP 水凝胶在增加 VEGF 和 CD31 表达、加速肉芽组织再生和促进伤口愈合方面表现出更好的能力。这项工作为皮肤组织工程领域中按需制造多功能水凝胶提供了一种新策略。
