Bains Ashank, Mur Taha, Wallace Nathan, Noordzij Jacob Pieter
Department of Otolaryngology-Head and Neck Surgery, Boston University School of Medicine, Boston, MA 02118, USA.
Department of Otolaryngology-Head and Neck Surgery, Boston Medical Center, Boston, MA 02118, USA.
Cancers (Basel). 2021 Jul 14;13(14):3516. doi: 10.3390/cancers13143516.
The role of vitamin D in modulating several cancer-related pathways has received an increasing amount of attention in the past several years. Previous literature has found an abundance of evidence of vitamin D exerting an anti-proliferative, anti-inflammatory, and pro-differentiation effect in various types of cancers including breast, colon, prostate, and pancreatic cancer. Although the link between vitamin D and thyroid cancer remains controversial, both biochemical evidence and clinical studies have attempted to establish a link between papillary thyroid carcinoma (PTC) and vitamin D status. Furthermore, the use of vitamin D as a prognostic marker has received increased attention, both in regards to clinical outcomes and cancer staging. In this review, we briefly discuss the metabolism and proposed mechanism of action of vitamin D in the context of PTC, and explore links between modulators in the vitamin D pathway and progression of PTC. We provide evidence from both clinical studies as well as molecular studies of metabolic targets, including vitamin D receptor and activating enzymes exerting an effect on PTC tissue, which indicate that vitamin D may play a significant prognostic role in PTC.
在过去几年中，维生素D在调节多种癌症相关通路中的作用受到了越来越多的关注。以往文献发现了大量证据，表明维生素D在包括乳腺癌、结肠癌、前列腺癌和胰腺癌在内的各种癌症中发挥抗增殖、抗炎和促分化作用。尽管维生素D与甲状腺癌之间的联系仍存在争议，但生化证据和临床研究都试图建立甲状腺乳头状癌（PTC）与维生素D状态之间的联系。此外，维生素D作为一种预后标志物，在临床结局和癌症分期方面都受到了更多关注。在本综述中，我们简要讨论了维生素D在PTC背景下的代谢及作用机制，并探讨了维生素D通路中的调节因子与PTC进展之间的联系。我们提供了临床研究以及代谢靶点分子研究的证据，包括维生素D受体和激活酶对PTC组织产生影响，这表明维生素D可能在PTC中发挥重要的预后作用。
