Zhao Duoyi, Zhu Tongtong, Li Jie, Cui Liguo, Zhang Zhiyu, Zhuang Xiuli, Ding Jianxun
Key Laboratory of Polymer Ecomaterials, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, 5625 Renmin Street, Changchun, 130022, PR China.
Department of Orthopedics, The Fourth Affiliated Hospital of China Medical University, 4 Chongshandong Road, Shenyang, 110032, PR China.
Bioact Mater. 2020 Aug 29;6(2):346-360. doi: 10.1016/j.bioactmat.2020.08.016. eCollection 2021 Feb.
Research and development of the ideal artificial bone-substitute materials to replace autologous and allogeneic bones for repairing bone defects is still a challenge in clinical orthopedics. Recently, poly(lactic--glycolic acid) (PLGA)-based artificial bone-substitute materials are attracting increasing attention as the benefit of their suitable biocompatibility, degradability, mechanical properties, and capabilities to promote bone regeneration. In this article, we comprehensively review the artificial bone-substitute materials made from PLGA or the composites of PLGA and other organic and inorganic substances, elaborate on their applications for bone regeneration with or without bioactive factors, and prospect the challenges and opportunities in clinical bone regeneration.
研发理想的人工骨替代材料以取代自体骨和异体骨来修复骨缺损仍是临床骨科面临的一项挑战。近年来，基于聚乳酸-乙醇酸共聚物（PLGA）的人工骨替代材料因其具有合适的生物相容性、可降解性、机械性能以及促进骨再生的能力而受到越来越多的关注。在本文中，我们全面综述了由PLGA或PLGA与其他有机和无机物质的复合材料制成的人工骨替代材料，阐述了它们在有或无生物活性因子情况下用于骨再生的应用，并展望了临床骨再生中的挑战与机遇。
