天然深共晶溶剂从. 中萃取亲水性和疏水性化合物的效果。

Efficacy of Natural Deep Eutectic Solvents for Extraction of Hydrophilic and Lipophilic Compounds from .

机构信息

Murmansk Marine Biological Institute of the Russian Academy of Sciences (MMBI RAS), Vladimirskaya, 17, 183010 Murmansk, Russia.

Department of Technology of Pharmaceutical Formulations, St. Petersburg State Chemical Pharmaceutical University, Prof. Popov, 14, 197376 Saint-Petersburg, Russia.

出版信息

Molecules. 2021 Jul 10;26(14):4198. doi: 10.3390/molecules26144198.

The impact of the composition of natural deep eutectic solvents (NADES) and extraction conditions on the simultaneous extraction of hydrophilic ascorbic acid (AA), phlorotannins (TPhC), and lipophilic fucoxanthin (FX) from was investigated for the first time. In biological tests, the NADES extracts showed the promising ability to scavenge DPPH radicals. A positive correlation was observed between DPPH scavenging activity and AA, TPhC, and FX contents. We calculate the synergistic effect of antioxidants extracted by NADES from based on the mixture effect (ME). The addition of 30% water to the NADES and the prolongation of sonication time from 20 min up to 60 min were favorable for the ME. The ME for extracts with the NADES was increased by two folds (ME > 2). In contrast, conventional extraction by maceration with steering at 60 °C does not lead to the synergistic effect (ME = 1). It is notable that the NADES provides high stability and preserves the antioxidant activity of the extracts from during storage.

首次研究了天然深共晶溶剂（NADES）的组成和提取条件对同时从海带中提取亲水性抗坏血酸（AA）、岩藻黄质（TPhC）和脂溶性岩藻黄素（FX）的影响。在生物测试中，NADES 提取物显示出清除 DPPH 自由基的有希望的能力。DPPH 清除活性与 AA、TPhC 和 FX 含量之间存在正相关关系。我们根据混合物效应（ME）计算了 NADES 从海带中提取的抗氧化剂的协同作用。将 30%的水添加到 NADES 中，并将超声时间从 20 分钟延长至 60 分钟，有利于 ME。NADES 提取物的 ME 增加了两倍（ME > 2）。相比之下，在 60°C 下搅拌的常规浸提不会产生协同作用（ME = 1）。值得注意的是，NADES 提供了高稳定性，并在储存过程中保持了提取物的抗氧化活性。