Section of Pharmacology, Department of Drug and Health Sciences, University of Catania, 95123 Catania, Italy.
Oasi Research Institute IRCCS, 94018 Troina, Italy.
Molecules. 2021 Jul 15;26(14):4291. doi: 10.3390/molecules26144291.
Citrus fruits are a rich source of high-value bioactive compounds and their consumption has been associated with beneficial effects on human health. Red (blood) oranges ( L. Osbeck) are particularly rich in anthocyanins (95% of which are represented by cyanidin-3-glucoside and cyanidin-3-6″-malonyl-glucoside), flavanones (hesperidin, narirutin, and didymin), and hydroxycinnamic acids (caffeic acid, coumaric acid, sinapic, and ferulic acid). Lemon fruit () is also rich in flavanones (eriocitrin, hesperidin, and diosmin) and other polyphenols. All of these compounds are believed to play a very important role as dietary antioxidants due to their ability to scavenge free radicals. A standardized powder extract, red orange and lemon extract (RLE), was obtained by properly mixing anthocyanins and other polyphenols recovered from red orange processing waste with eriocitrin and other flavanones recovered from lemon peel by a patented extraction process. RLE was used for in vivo assays aimed at testing a potential beneficial effect on glucose and lipid metabolism. In vivo experiments performed on male CD1 mice fed with a high-fat diet showed that an 8-week treatment with RLE was able to induce a significant reduction in glucose, cholesterol and triglycerides levels in the blood, with positive effects on regulation of hyperglycemia and lipid metabolism, thus suggesting a potential use of this new phytoextract for nutraceutical purposes.
柑橘类水果是高价值生物活性化合物的丰富来源，其消费与对人类健康的有益影响有关。红（血）橙（ L. Osbeck）特别富含花青素（其中 95%由矢车菊素-3-葡萄糖苷和矢车菊素-3-6″-丙二酰葡萄糖苷组成）、类黄酮（柚皮苷、柚皮苷、二氢查耳酮）和羟基肉桂酸（咖啡酸、香豆酸、芥子酸和阿魏酸）。柠檬果实（）也富含类黄酮（橙皮苷、柚皮苷和地奥司明）和其他多酚。由于其清除自由基的能力，所有这些化合物都被认为是非常重要的膳食抗氧化剂，因为它们能够清除自由基。红橙和柠檬提取物（RLE）是通过适当混合从红橙加工废物中回收的花青素和其他多酚，以及从柠檬皮中回收的橙皮苷和其他类黄酮，通过专利提取工艺获得的标准化粉末提取物。RLE 用于体内试验，旨在测试其对葡萄糖和脂质代谢的潜在有益作用。在高脂饮食喂养的雄性 CD1 小鼠上进行的体内实验表明，RLE 治疗 8 周可显著降低血液中的葡萄糖、胆固醇和甘油三酯水平，对调节高血糖和脂质代谢有积极作用，因此表明这种新型植物提取物具有潜在的营养用途。
