Sakamoto Y, Kamada M, Shitsukawa K, Yasui T, Furumoto H, Mori K, Daitoh T, Irahara M, Kishi Y, Aono T
Department of Obstetrics and Gynecology, School of Medicine, University of Tokushima.
Nihon Sanka Fujinka Gakkai Zasshi. 1987 Nov;39(11):1980-6.
The expression of Thomsen-Friedenreich antigen (T-Ag), the precursor of MN blood group antigen, was studied by the ABC method with Arachys Hypogaea lectin (PNA) and the relationship of the results to the histology and clinical behavior of primary gynecologic cancers were examined. The results were as follows: 1. In cervical squamous cell tumors, the incidence of the expression of T-Ag in invasive cancers (52.9%, 37/70) was significantly higher (p less than 0.05) than that in intraepithelial tumors (28.6%, 8/28). No cryptic T-Ag(-) tissue was found in intraepithelial tumors or microinvasive cancers. 2. In squamous cell carcinomas of the cervix, the incidence of cryptic T-Ag(-) tissue was high (36.4%, 4/11) in tissue of the small cell non-keratinizing type, the most undifferentiated type, whereas it was not found in 5 cases of well-differentiated keratinizing carcinoma examined. 3. In stage Ib and II cervical cancers, no relationship was recognized between the expression of T-Ag in primary lesion and extension to the parametrium or the pelvic lymph nodes. 4. The incidence of T-Ag(+) tissue in adenocarcinomas of the uterine cervix (62.5%, 5/8), the endometrium (91.7%, 11/12), and the ovarian (80%, 8/10) was higher than that in squamous cell carcinoma of the uterine cervix (52.5%, 32/61). 5. In endometrial cancers, no relationship was recognized between the expression of T-Ag and hormone receptor status.
采用花生凝集素（PNA）通过ABC法研究了MN血型抗原前体汤姆森 - 弗里德赖希抗原（T抗原）的表达，并检测了结果与原发性妇科癌症组织学及临床行为的关系。结果如下：1. 在宫颈鳞状细胞瘤中，浸润性癌中T抗原表达的发生率（52.9%，37/70）显著高于上皮内肿瘤（28.6%，8/28）（p<0.05）。在上皮内肿瘤或微浸润癌中未发现隐匿性T抗原阴性组织。2. 在宫颈鳞状细胞癌中，小细胞非角化型（最未分化型）组织中隐匿性T抗原阴性组织的发生率较高（36.4%，4/11），而在所检查的5例高分化角化癌中未发现。3. 在Ib期和II期宫颈癌中，原发灶中T抗原的表达与向宫旁组织或盆腔淋巴结的扩散之间未发现相关性。4. 子宫颈腺癌（62.5%，5/8）、子宫内膜癌（91.7%，11/12）和卵巢癌（80%，8/10）中T抗原阳性组织的发生率高于子宫颈鳞状细胞癌（52.5%，32/61）。5. 在子宫内膜癌中，T抗原的表达与激素受体状态之间未发现相关性。
