Department of Occupational and Environmental Medicine, Kangbuk Samsung Hospital, School of Medicine, Sungkyunkwan University, Seoul 03181, Korea.
Department of Occupational and Environmental Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul 06591, Korea.
Int J Environ Res Public Health. 2021 Jul 13;18(14):7458. doi: 10.3390/ijerph18147458.
As shift work has become prevalent globally, it is important to evaluate the health effects of shift work on employees. Several studies have demonstrated a positive association between shift work and prostate cancer. Therefore, we aimed to further examine the relationship between shift work and elevated prostate-specific antigen (PSA). Our study collected data from 66,817 male participants at baseline and followed up for about 6 years. We categorized shift worker status and shift schedule types. To evaluate the risk of elevated PSA on shift workers, we estimated hazard ratios using the Cox proportional hazards regression analyses. During a median follow-up of 4.1 years, 1030 participants developed elevated PSA. The multivariable-adjusted hazard ratio (HR) of elevated PSA for shift workers compared with daytime workers was 1.37 (1.04-1.80). Among shift workers, rotating shift workers (HR = 1.47, 95% CI 1.06-2.03) showed a significantly increased risk of elevated PSA compared with daytime workers. Our longitudinal study provides evidence for an association between shift work, especially rotating shift work, and elevations of PSA.
随着轮班工作在全球范围内的普遍化，评估轮班工作对员工健康的影响变得尤为重要。多项研究表明，轮班工作与前列腺癌之间存在正相关关系。因此，我们旨在进一步研究轮班工作与前列腺特异性抗原（PSA）升高之间的关系。本研究在基线时收集了 66817 名男性参与者的数据，并进行了大约 6 年的随访。我们对轮班工人的状态和轮班时间表类型进行了分类。为了评估轮班工人 PSA 升高的风险，我们使用 Cox 比例风险回归分析估计了风险比。在中位数为 4.1 年的随访期间，有 1030 名参与者出现 PSA 升高。与白班工人相比，轮班工人 PSA 升高的多变量调整风险比（HR）为 1.37（1.04-1.80）。在轮班工人中，与白班工人相比，倒班工人（HR=1.47，95%CI 1.06-2.03）的 PSA 升高风险显著增加。我们的纵向研究为轮班工作，特别是倒班工作与 PSA 升高之间的关联提供了证据。
