Department of Transfusion Medicine, Sree Chitra Tirunal Institute Of Medical Sciences And Technology, Trivandrum, 695011, Kerala, India.
Department of Transfusion Medicine, Sree Chitra Tirunal Institute of Medical Sciences and Technology, Trivandrum, 695011, Kerala, India.
Transfus Apher Sci. 2021 Dec;60(6):103214. doi: 10.1016/j.transci.2021.103214. Epub 2021 Jul 16.
The increment in a patient's haemoglobin level is based upon the haemoglobin content of the transfused RBC units. The total haemoglobin present in the blood bags can vary because of the blood donor, processing method, volume and type of bag used. The study is done to analyse the factors causing variation of haemoglobin content in RBC units.
A total of 260 RBC units were tested for the haemoglobin content and analysed with the donor variables (age, gender, weight & capillary haemoglobin). The blood bags were then separated into two groups based on the donor capillary haemoglobin (normal 12.5-15.0 g/dL vs high 15.1-18.0 g/dL), volume (350 vs 450 mL), processing method (Platelet rich plasma vs buffy coat) and further analysis was carried out.
The mean haemoglobin content was 54.7 g ranging from 34.2-80 g per unit. The factors which significantly influenced (p < 0.0001) were capillary haemoglobin, gender and weight of donor, volume of blood collected and the processing method. There was a significant difference (p < 0.0001) in haemoglobin content between the two groups in all the three categories (capillary haemoglobin, volume and processing method). Regression analysis showed all three of them contributed to 80 % variability of haemoglobin content in the RBC unit.
The marked variation of haemoglobin content in our study revealed that there is a need for standardizing RBC unit. Labelling of units with haemoglobin content and transfusion based on it will result in better patient care.
患者的血红蛋白水平升高取决于输注的红细胞单位中的血红蛋白含量。由于献血者、处理方法、血袋体积和类型的不同，血袋中的总血红蛋白含量可能会有所不同。本研究旨在分析导致红细胞单位中血红蛋白含量变化的因素。
共检测了 260 个红细胞单位的血红蛋白含量，并对献血者变量（年龄、性别、体重和毛细血管血红蛋白）进行了分析。然后，根据献血者毛细血管血红蛋白（正常 12.5-15.0 g/dL 与高 15.1-18.0 g/dL）、体积（350 vs 450 mL）、处理方法（富含血小板血浆与白细胞层）将血袋分为两组，并进行进一步分析。
平均血红蛋白含量为 54.7 g，范围为 34.2-80 g/单位。显著影响（p < 0.0001）的因素有：献血者的毛细血管血红蛋白、性别和体重、采集的血量以及处理方法。在所有三个类别（毛细血管血红蛋白、体积和处理方法）中，两组之间的血红蛋白含量均存在显著差异（p < 0.0001）。回归分析显示，这三个因素共同导致了红细胞单位中血红蛋白含量的 80%的可变性。
我们的研究表明血红蛋白含量存在显著差异，因此需要对红细胞单位进行标准化。对单位进行血红蛋白含量标记并根据其进行输血将有助于更好地照顾患者。
