ICMR-National Institute for Research in Tuberculosis, Chennai, India.
ICMR-National Institute for Research in Tuberculosis, Chennai, India.
Int J Infect Dis. 2021 Sep;110:98-104. doi: 10.1016/j.ijid.2021.07.041. Epub 2021 Jul 22.
BCG can improve the response to vaccines directed against viral infections, and also, BCG vaccination reduces all-cause mortality, most likely by protecting against unrelated infections. However, the effect of BCG vaccination on dendritic cell (DC) subsets is not well characterized.
We investigated the impact of BCG vaccination on the frequencies of DC subsets and type I and III interferons (IFNs) using whole blood and plasma samples in a group of elderly individuals (age 60-80 years) at one-month post-vaccination as part of our clinical study to examine the effect of BCG on COVID-19.
Our results demonstrate that BCG vaccination induced enhanced frequencies of plasmacytoid DC (pDC) and myeloid DC (mDC). BCG vaccination also induced diminished plasma levels of type I IFNs, IFNα and IFNβ but increased levels of type III IFNs, IL-28A and IL-29.
Thus, BCG vaccination was associated with enhanced DC subsets and IL-28A/IL-29 in elderly individuals, suggesting its ability to induce non-specific innate immune responses.
卡介苗（BCG）可提高针对病毒感染的疫苗反应，并且 BCG 疫苗接种可降低全因死亡率，这很可能是通过预防无关感染来实现的。然而，BCG 疫苗接种对树突状细胞（DC）亚群的影响尚未得到很好的描述。
我们在一项针对 COVID-19 的临床试验中，在接种疫苗后一个月，使用全血和血浆样本，研究了 BCG 疫苗接种对 DC 亚群和 I 型和 III 型干扰素（IFN）的频率的影响，该研究纳入了一组老年人（60-80 岁）。
我们的结果表明，BCG 疫苗接种可诱导浆细胞样 DC（pDC）和髓样 DC（mDC）的频率增加。BCG 疫苗接种还可降低 I 型 IFN、IFNα 和 IFNβ 的血浆水平，但增加 III 型 IFN、IL-28A 和 IL-29 的水平。
因此，BCG 疫苗接种与老年人中 DC 亚群和 IL-28A/IL-29 的增加有关，这表明其诱导非特异性先天免疫反应的能力。
