Hansen Morten Steen, Frost Morten
Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital, DK-5000 Odense, Denmark.
Molecular Endocrinology Laboratory (KMEB), Department of Endocrinology, Odense University Hospital, DK-5000 Odense, Denmark.
Semin Cell Dev Biol. 2022 Mar;123:74-81. doi: 10.1016/j.semcdb.2021.06.024. Epub 2021 Jul 22.
Gut hormones secreted from enteroendocrine cells following nutrient ingestion modulate metabolic processes including glucose homeostasis and food intake, and several of these gut hormones are involved in the regulation of the energy demanding process of bone remodelling. Here, we review the gut hormones considered or known to be involved in the gut-bone crosstalk and their role in orchestrating adaptions of bone formation and resorption as demonstrated in cellular and physiological experiments and clinical trials. Understanding the physiology and pathophysiology of the gut-bone axis may identify adverse effects of investigational drugs aimed to treat metabolic diseases such as type 2 diabetes and obesity and new therapeutic candidates for the treatment of bone diseases.
营养物质摄入后，肠内分泌细胞分泌的肠道激素可调节包括葡萄糖稳态和食物摄入在内的代谢过程，其中几种肠道激素参与了对骨重塑这一高能量需求过程的调节。在此，我们综述了被认为或已知参与肠-骨相互作用的肠道激素，以及它们在协调骨形成和吸收适应性方面的作用，这在细胞和生理学实验以及临床试验中均有体现。了解肠-骨轴的生理学和病理生理学，可能有助于识别旨在治疗2型糖尿病和肥胖症等代谢性疾病的研究性药物的不良反应，以及发现治疗骨疾病的新候选疗法。
