Gribble Fiona M, Reimann Frank
Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Metabolic Research Laboratories, WT-MRC Institute of Metabolic Science, Addenbrooke's Hospital, Hills Road, Cambridge CB2 0QQ, UK.
Physiol Behav. 2017 Jul 1;176:183-188. doi: 10.1016/j.physbeh.2017.02.039. Epub 2017 Feb 28.
Enteroendocrine cells are sensory cells located in the intestinal epithelium that produce a variety of hormonal regulators of gastrointestinal physiology, metabolism and food intake. They detect the absorption of a wide range of ingested nutrients via pathways that include transporter-mediated uptake, G-protein coupled receptors and ion channels. This review will describe mechanisms by which the L-cells that produce Glucagon Like Peptide-1 (GLP-1) respond to different components of ingested food, and the importance of these pathways not only for understanding physiology, but also for developing new treatments for type 2 diabetes and obesity.
肠内分泌细胞是位于肠上皮的感觉细胞，可产生多种调节胃肠生理、代谢和食物摄入的激素。它们通过包括转运体介导的摄取、G蛋白偶联受体和离子通道在内的途径检测多种摄入营养素的吸收情况。本综述将描述产生胰高血糖素样肽-1（GLP-1）的L细胞对摄入食物不同成分作出反应的机制，以及这些途径不仅对于理解生理学，而且对于开发2型糖尿病和肥胖症新疗法的重要性。
