Abulikemu Yiming, Abulajang Tohti, Ailigen Abdureyimu, Tang Liang
Otorhinolaryngology Clinic，People's Hospital of Xinjiang Uygur Autonomous Region，Urumqi，830000，China.
Lin Chuang Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2021 Aug;35(8):728-732. doi: 10.13201/j.issn.2096-7993.2021.08.012.
To explore the correlation between the levels of inflammatory factors and their gene polymorphisms and the susceptibility to obstructive sleep apnea（OSA）. Seventy-nine patients who were diagnosed with OSA in People's Hospital of Xinjiang Uygur Autonomous Region from October 2018 to December 2020 were selected as the study group, and 104 healthy adults who received physical examination during the same period were selected as the control group. After collecting the clinical data of the two groups of patients, the two groups of patients were matched by propensity scores. Then, the serum IL-6, IL-8 and TNF-α levels and the peripheral blood IL-6, IL-8 and TNF-α gene polymorphism analysis and comparison were performed on the included matched patients. Before matching, the age, proportion of males, BMI, neck circumference, smoking history, SBP and DBP of the study group were higher than those of the control group, and the difference was statistically significant（<0.05）. After the two groups of patients were matched by propensity scores, a total of 67 patients were successfully matched. The covariates between the two groups were all balanced after matching, and the balance of the PSM covariates was significantly improved（>0.05）. After matching, the fasting blood glucose, C-reactive protein, IL-6, IL-8, TNF-α, AHI and Ts90% of the study group were significantly higher than those of the control group, and the difference was statistically significant（<0.05）. Hardy-Weinberg balance verifies that the gene frequencies of each group are in accordance with the genetic balance rule（>0.05）; after matching, the distribution of IL-6（rs1800795） and TNF-α（rs1800629） genotypes between the two groups is compared, and the difference is statistically significant scientific significance; the frequency of IL-6（rs1800795） allele C and the frequency of TNF-α（rs1800629） allele A in the study group were significantly higher than those in the control group, and the difference was statistically significant（<0.05）. The levels of inflammatory factors TNF-α and IL-6 and their gene polymorphisms are significantly related to the susceptibility to OSA.
探讨炎症因子水平及其基因多态性与阻塞性睡眠呼吸暂停（OSA）易感性之间的相关性。选取2018年10月至2020年12月在新疆维吾尔自治区人民医院被诊断为OSA的79例患者作为研究组，选取同期进行体检的104例健康成年人作为对照组。收集两组患者的临床资料后，采用倾向得分对两组患者进行匹配。然后，对纳入的匹配患者进行血清IL-6、IL-8和TNF-α水平以及外周血IL-6、IL-8和TNF-α基因多态性分析和比较。匹配前，研究组的年龄、男性比例、BMI、颈围、吸烟史、收缩压和舒张压均高于对照组，差异有统计学意义（<0.05）。两组患者经倾向得分匹配后，共成功匹配67例患者。匹配后两组间协变量均达到平衡，PSM协变量的平衡性显著改善（>0.05）。匹配后，研究组的空腹血糖、C反应蛋白、IL-6、IL-8、TNF-α、呼吸暂停低通气指数（AHI）和TS90%均显著高于对照组，差异有统计学意义（<0.05）。Hardy-Weinberg平衡检验证实各组基因频率符合遗传平衡规律（>0.05）；匹配后，比较两组间IL-6（rs1800795）和TNF-α（rs1800629）基因型分布，差异有统计学意义；研究组中IL-6（rs1800795）等位基因C频率和TNF-α（rs1800629）等位基因A频率均显著高于对照组，差异有统计学意义（<0.05）。炎症因子TNF-α和IL-6水平及其基因多态性与OSA易感性显著相关。
