SARS-CoV-2 受体“ACE2”在人胰腺 β 细胞中的表达：是与否！
Expression of SARS-CoV-2 receptor "ACE2" in human pancreatic β cells: to be or not to be!
机构信息
Department of Basic Medical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates (UAE).
Department of Basic sciences, Sharjah Institute for Medical Research, Sharjah, University of Sharjah, United Arab Emirates (UAE).
出版信息
Islets. 2021 Sep 3;13(5-6):106-114. doi: 10.1080/19382014.2021.1954458. Epub 2021 Jul 24.
The current COVID-19 pandemic, which continues to spread across the globe, is caused by severe acute respiratory syndrome coronavirus (SARS-Cov-2). Soon after the pandemic emerged in China, it became clear that the receptor-binding domain (RBD) of angiotensin-converting enzyme 2 () serves as the primary cell surface receptor for SARS-Cov-2. Subsequent work has shown that diabetes and hyperglycemia are major risk factors for morbidity and mortality in COVID-19 patients. However, data on the pattern of expression of on human pancreatic β cells remain contradictory. Additionally, there is no consensus on whether the virus can directly infect and damage pancreatic islets and hence exacerbate diabetes. In this mini-review, we highlight the role of receptor and summarize the current state of knowledge regarding its expression/co-localization in human pancreatic endocrine cells. We also discuss recent data on the permissiveness of human pancreatic β cells to SARS-Cov-2 infection.
当前的 COVID-19 大流行仍在全球范围内蔓延，它是由严重急性呼吸系统综合症冠状病毒 2 型（SARS-CoV-2）引起的。在中国出现大流行后不久，人们就清楚地认识到血管紧张素转化酶 2（ACE2）的受体结合域（RBD）是 SARS-CoV-2 的主要细胞表面受体。随后的研究表明，糖尿病和高血糖是 COVID-19 患者发病率和死亡率的主要危险因素。然而，关于 ACE2 在人胰腺β细胞上的表达模式的数据仍然存在矛盾。此外，关于该病毒是否可以直接感染和损伤胰岛并因此加重糖尿病，目前也没有共识。在这篇小型综述中，我们强调了 ACE2 受体的作用，并总结了目前关于其在人胰腺内分泌细胞中的表达/共定位的知识状况。我们还讨论了关于人胰腺β细胞对 SARS-CoV-2 感染易感性的最新数据。
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