Pistoresi-Palencia M C, Galmarini M, Vottero-Cima E
Cátedra de Immunología y Serología Facultad de Ciencias Químicas, Universidad Nacional Cordoba, Argentina.
J Reprod Immunol. 1987 Nov;12(3):215-23. doi: 10.1016/0165-0378(87)90025-8.
The effect of aging on the immune response to autoantigen of rat male accessory glands (RAG) was studied in Wistar rats. Male and female rats, 3 and 12 months old, were immunized with chemically modified RAG and heterologous antigen (human serum albumin, HSA). The study of delayed type hypersensitivity (DTH) and antibodies against RAG revealed a higher response in 12-month-old animals than in 3-month-old animals (P less than 0.005), regardless of their sexes. No differences in DTH and humoral responses to HSA were observed. Experiments on the transfer of spleen cells showed an increase in response elicited by RAG immunization in young recipients of cells from normal or immunized old syngeneic donors. On the contrary, old recipients of spleen cells from normal or immunized young donors maintained their high response the same as non-transferred old rats. Therefore, both the lymphoid cells and the environment in which the response was elicited seem to be involved in the increase of the autoimmune response.
在Wistar大鼠中研究了衰老对大鼠雄性附属性腺（RAG）自身抗原免疫反应的影响。对3个月和12个月大的雄性和雌性大鼠用化学修饰的RAG和异源抗原（人血清白蛋白，HSA）进行免疫。对迟发型超敏反应（DTH）和抗RAG抗体的研究表明，12个月大的动物比3个月大的动物反应更高（P小于0.005），无论其性别如何。未观察到对HSA的DTH和体液反应有差异。脾细胞转移实验表明，来自正常或免疫的同基因老年供体的细胞的年轻受体中，RAG免疫引发的反应增加。相反，来自正常或免疫的年轻供体的脾细胞的老年受体保持与未转移的老年大鼠相同的高反应性。因此，淋巴细胞和引发反应的环境似乎都与自身免疫反应的增加有关。
