Ferro M E, Yranzo-Volonté N, Riera C M
Cátedra de Inmunología y Serología, Facultad de Ciencias Químicas,Universidad Nacional de Córdoba, Argentina.
Immunol Lett. 1987 Nov;16(2):125-32. doi: 10.1016/0165-2478(87)90119-2.
We have examined the mechanism of suppression of autoimmunity to rat male accessory glands (RAG) by T suppressor cells. This suppression was accomplished by transfer to syngeneic rats of spleen mononuclear (SpM) cells from rats rendered unresponsive by pretreatment with low doses of a purified fraction of RAG (containing the autoantigen). The experiments demonstrated that the suppressor cells that act on the inducer phase of the suppression are cyclophosphamide (Cy) sensitive and that they can be positively selected on antigen-coated plates. On the other hand, the inducer phase T suppressor cells present on spleens coming from antigen-pretreated rats did not suppress the autoimmune response in normal recipients that had been irradiated (850 rad 137Cs) just prior to receiving the cells or injected with Cy 14 days after transfer. The results indicate that the regulation of immune response to the autoantigen of RAG is complex and that it involves the interaction of many cell types.
我们研究了抑制性T细胞对大鼠雄性附属腺（RAG）自身免疫的抑制机制。这种抑制作用是通过将经低剂量纯化的RAG组分（含自身抗原）预处理而变得无反应的大鼠的脾脏单核细胞（SpM）转移至同基因大鼠来实现的。实验表明，作用于抑制诱导阶段的抑制细胞对环磷酰胺（Cy）敏感，并且它们可以在抗原包被的平板上被阳性选择。另一方面，来自经抗原预处理大鼠脾脏的诱导阶段抑制性T细胞，在正常受体接受细胞前刚接受照射（850拉德137铯）或在转移后14天注射Cy的情况下，不能抑制自身免疫反应。结果表明，对RAG自身抗原的免疫反应调节是复杂的，并且涉及多种细胞类型的相互作用。
