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威尔斯综合征作为单侧上睑下垂的罕见病因。

Wells Syndrome as a Rare Cause of Unilateral Ptosis.

作者信息

Janssen Caroline, Lauwers Noémie, Leysen Inge

机构信息

Department of Ophthalmology, University Hospital of Antwerp, Edegem, Belgium.

出版信息

Ocul Oncol Pathol. 2021 Jun;7(3):190-193. doi: 10.1159/000511595. Epub 2021 Jan 28.

DOI:10.1159/000511595
PMID:34307331
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8280402/
Abstract

We present a case of a woman with a swollen upper eyelid in ptosis, conjunctival nodules, and chemosis present for a couple of weeks. She did not respond to therapy for hordeolum or allergy. A biopsy followed by histopathological examination showed a large infiltration of eosinophilic granulocytes and flame figures, so the diagnosis of Wells syndrome was made. Oral methylprednisolone in high dose was necessary, and tapering was slow because of frequent bouts of relapse. After 3 months, the swelling and hard feeling of the eyelid disappeared, but a slight ptosis remained. Eyelid swelling and eosinophilia recurred 18 months after resolution of the first episode.

摘要

我们报告一例女性病例,该患者上睑肿胀伴上睑下垂、结膜结节及球结膜水肿,持续数周。她对睑腺炎或过敏治疗均无反应。活检及组织病理学检查显示大量嗜酸性粒细胞浸润及火焰状图形,因此诊断为韦尔斯综合征。需要使用高剂量口服甲泼尼龙,且由于频繁复发,减量过程缓慢。3个月后,眼睑肿胀及硬结感消失,但仍遗留轻度上睑下垂。首次发作缓解18个月后,眼睑肿胀及嗜酸性粒细胞增多再次出现。

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1
Wells Syndrome as a Rare Cause of Unilateral Ptosis.威尔斯综合征作为单侧上睑下垂的罕见病因。
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2
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Eosinophilic infiltration with flame figures. A distinctive tissue reaction seen in Wells' syndrome and other diseases.伴有火焰状细胞的嗜酸性粒细胞浸润。这是在威尔斯综合征和其他疾病中可见的一种独特的组织反应。
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本文引用的文献

1
[Wells syndrome mimicking facial cellulitis: Three cases].[酷似面部蜂窝织炎的威尔斯综合征:三例报告]
Ann Dermatol Venereol. 2017 Apr;144(4):284-289. doi: 10.1016/j.annder.2016.09.676. Epub 2016 Nov 10.
2
Treatment of eosinophilic cellulitis (Wells syndrome) - a systematic review.嗜酸性粒细胞性蜂窝织炎(韦尔斯综合征)的治疗——一项系统评价
J Eur Acad Dermatol Venereol. 2016 Sep;30(9):1465-79. doi: 10.1111/jdv.13706. Epub 2016 Jun 29.
3
Recurrent paraneoplastic wells syndrome in a patient with metastatic renal cell cancer.一名转移性肾细胞癌患者的复发性副肿瘤性韦尔斯综合征
Dermatol Online J. 2014 Jun 15;20(6):13030/qt35w8r1g3.
4
Wells' syndrome associated with parvovirus in a 5-year old boy.一名5岁男孩中与细小病毒相关的威尔斯综合征。
Pediatr Dermatol. 2012 Nov-Dec;29(6):762-4. doi: 10.1111/j.1525-1470.2011.01619.x. Epub 2011 Dec 9.
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A patient with Wells' syndrome.一名患有威尔斯综合征的患者。
Clin Exp Dermatol. 2010 Apr;35(3):e3-4. doi: 10.1111/j.1365-2230.2008.03132.x.
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Wells syndrome in adults and children: a report of 19 cases.成人和儿童的威尔斯综合征:19例报告
Arch Dermatol. 2006 Sep;142(9):1157-61. doi: 10.1001/archderm.142.9.1157.
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Eosinophilic cellulitis (Wells' syndrome) associated with colon carcinoma.嗜酸性粒细胞性蜂窝织炎(韦尔斯综合征)与结肠癌相关。
J Dtsch Dermatol Ges. 2005 Jul;3(7):530-1. doi: 10.1111/j.1610-0387.2005.05726.x.
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Wells' syndrome: a clinical and histopathologic review of seven cases.韦尔斯综合征:7例临床及组织病理学回顾
Int J Dermatol. 2003 Jan;42(1):62-7. doi: 10.1046/j.1365-4362.2003.01705.x.
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Eosinophilic cellulitis associated with squamous cell carcinoma of the bronchus.嗜酸性粒细胞性蜂窝织炎与支气管鳞状细胞癌相关。
Br J Dermatol. 2001 Oct;145(4):678-9. doi: 10.1046/j.1365-2133.2001.04418.x.
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Wells' syndrome: report of a case and review of the literature.威尔斯综合征:一例报告及文献综述
Int J Dermatol. 2001 Feb;40(2):148-52.