Department of Pediatrics, University of Washington, Box 357920, Seattle, WA, 98195, USA.
Department of Speech and Hearing Sciences, University of Washington, Seattle, WA, USA.
J Autism Dev Disord. 2022 Jul;52(7):3304-3313. doi: 10.1007/s10803-021-05190-7. Epub 2021 Jul 26.
We examined the relationship between the Early start Denver model (ESDM) intervention and mu rhythm attenuation, an EEG paradigm reflecting neural processes associated with action perception and social information processing. Children were assigned to either receive comprehensive ESDM intervention for two years, or were encouraged to pursue resources in the community. Two years after intervention, EEG was collected during the execution and observation of grasping actions performed by familiar and unfamiliar agents. The ESDM group showed significantly greater attenuation when viewing a parent or caregiver executing a grasping action, compared with an unfamiliar individual executing the same action. Our findings suggest that the ESDM may have a unique impact on neural circuitry underlying social cognition and familiarity.
我们研究了早期丹佛模式（ESDM）干预与 mu 节律抑制之间的关系，mu 节律抑制是一种脑电图范式，反映了与动作感知和社会信息处理相关的神经过程。将儿童分为接受为期两年的综合 ESDM 干预组，或鼓励他们在社区中寻找资源。干预两年后，在执行和观察熟悉和不熟悉的代理执行抓握动作时，记录脑电图。与执行相同动作的陌生个体相比，ESDM 组在观察父母或照顾者执行抓握动作时表现出明显更大的抑制。我们的发现表明，ESDM 可能对社交认知和熟悉度的神经回路产生独特的影响。
